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I Ia Erukhimovich

Publications and source records attributed to I Ia Erukhimovich.

2 recordsLinked to original sources

[On DNA compaction in diluted polymeric solutions].

Causes of compactization of double helical molecule of DNA in polyethylene glycol (PEG) solution are considered. The compactization mechanism is shown to be based on the displacement of PEG coil from the initiated globular DNA particle. An efficient virial coefficient of the interaction between DNA monomers through PEG chains is calculated. An efficient theta-point is found from PEG concentration. The experimental relationship between PEG critical concentration responding to the onset of compactization and PEG molecular weight is analysed. The absence of DNA compactization and PEG molecular weight is analysed. The absence of DNA compactization with PEG of low molecular weight is explained. Theoretical works on DNA compactization are reviewed.

DNA↗

[Theory of DNA compactization in a polymer solution].

A theory of DNA compactization is suggested. It is based on the concept about compact DNA globule as a polymeric one. The polymeric solution is considered as a strongly fluctuating system, and the double helical DNA as a rigid unifilar homopolymer. The globule is shown to appear in a diluted polymeric solution. The character of relative phase transition is analysed. With an increase of polymeric solution concentration the size of the DNA globule should decrease and the optic activity increase. Conditions are indicated under which the decompactization of DNA takes place at high concentrations of polymeric solution. This event is accompanied by an abrupt increase of DNA size and a decrease of optical activity.

Chemical Phenomena↗