[Ketoacidosis and ketoacidotic coma].
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Biomedical subjects
Publications and source records attributed to I Iu Demidova.
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The study confirmed the data on the absence of a stable compensation of diabetes mellitus in most patients with the insulin-dependent form of disease under domestic conditions. It was extremely difficult to maintain the state of compensation without active participation of patients instructed in therapeutic measures and control of disease. Therefore the most urgent problems of modern diabetology are to train patients, to encourage their participation in a therapeutic process and to provide facilities for determination of glycemia under domestic conditions.
The decompensation of the insulin-dependent type of diabetes mellitus under domestic conditions results from a low level of education of patients and their family members with regard to therapy of this disease, a formalistic attitude to doctor's recommendations and the absence of a regular control over a course of disease. Some patients and often physicians believe that the most effective measure for improving carbohydrate metabolism is to raise a dose of insulin which leads to the development of a syndrome of chronic overdosage and a more severe course of diabetes mellitus. The instruction of such patients with respect to the main therapeutic principles of this disease and their active participation in therapeutic measures and control over a course of disease will make it possible to raise the level of compensation in diabetes mellitus patients.
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Due to its pharmacokinetics, glurenorm (95% of the drug metabolite is withdrawn from the body with the bile) is widely used in patients with non-insulin-dependent diabetes mellitus (NIDDM) with disturbed renal function. It seemed that, bearing in mind the relationship between glurenorm elimination and liver function, this drug use in patients with NIDDM patients with liver diseases should be restricted. The aim of the present research was to study glurenorm effect on liver function. Eighteen patients with NIDDM and liver diseases, administered glurenorm, were followed up. No clinical or laboratory deterioration on the part of the liver were detected over the course of follow-up. The results evidence no negative effects of glurenorm on the kidneys or liver, therefore the drug may be used in the treatment of NIDDM patients with liver abnormalities.
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