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Biomedical subjects

I J Forbes

Publications and source records attributed to I J Forbes.

At least 91 records · Page 5Linked to original sources
PubMed1973

Immunological function in dystrophia myotonica.

Humoral and cellular immunity have been investigated in 15 patients with dystrophia myotonica. No abnormalities in total serum levels of the five major immunoglobulin classes were found but there was a rise in the mean serum level of beta(1)A complement. Altogether, 54% of patients failed to make antibody to tetanus toxoid as compared with 1% of controls: 13% of patients failed to make antibody to Salmonella typhi H antigen as compared with no failure of this function in control subjects. There was a reduced uptake of tritiated thymidine by whole blood lymphocyte cultures spontaneously, while in the presence of phytohaemagglutinin (PHA) and both autologous and fetal calf serum the uptake was normal. It is suggested that there may be a wider derangement of immunological function in dystrophia myotonica than previously thought.

Adolescent↗
PubMed1971

Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).

63 patients on long-term oral therapy with phenytoin sodium (sodium diphenylhydantoin) were screened for abnormalities of immunological function. They were compared with 92 controls and 28 patients with lymphoma. Depression of cellular or humoral immunity, or both, was found in a significant number of phenytoin-treated and lymphoma subjects. Phenytoin therapy was associated with low immunoglobulin A (21%), failure of antibody response to Salmonella typhi antigen (9%), absence of delayed hypersensitivity (D.H.S.) to three common skin-test antigens (22%), and depression of in-vitro lymphocyte transformation by phytohaemagglutinin (27%). Lymphoma patients manifested low IgM (22%), and inability to make antibody to S. typhi (11%) and to tetanus toxoid (21%). D.H.S. was absent in 36%; lymphocyte transformation was depressed in 17%. Abnormal lymphocyte transformation did not correlate with depression of cellular or humoral immunity in either group.

Adolescent↗