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Biomedical subjects

I Janson

Publications and source records attributed to I Janson.

25 records · Page 2Linked to original sources
PubMed1975

[Tongue pathology and its effect on the stomatognathous system in juvenile cerebral movement disorders].

Studies in 146 children with cerebral palsy revealed a definite relation between malfunctioning, size, and location of the lingual muscle and the development of the dentition. The results may be regarded as a confirmation of the so-called functional adaptation theory first observed by ROUX in 1921. The formative influence of the maxillo-facial musculature-including the musculature of the tongue-on the development of the dentition is determined by the proper interaction of the various groups of muscles. Oral muscular malfunctioning, as is often observed in children with cerebral palsy, therefore has a direct influence on the malformation of the jaws and the dentition.

Cerebral Palsy↗
PubMedDate not supplied

Calpain and calpastatin in normal and Alzheimer-degenerated human brain tissue.

The Ca2(+)-dependent neutral proteases calpain I and II as well as their specific inhibitor, calpastatin, were isolated from normal and Alzheimer-degenerated frozen human brain tissue. In the Alzheimer group calpain I activity was higher in cortex than in mesencephalon. The calpastatin activity was lower in cortex in both groups. This may implicate a higher Ca2(+)-dependent proteolysis in cortex compared to mesencephalon. In the Alzheimer group the cortical calpain II level decreased with an increasing degree of neuropathological changes. In the control group, the level of calpastatin decreased as the number of plaques and tangles increased. Evidence was obtained for a correlation of net calpain activity and the extent of neuropathological changes in cortex.

Aged↗
PubMedDate not supplied

Increased proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease.

The levels of calpains (m-calpain and mu-calpain) in peripheral blood lymphocytes from patients with Alzheimer's disease were determined via Western blotting. The Ca-dependent proteolytic activity and the calpastatin activity were estimated using incubation with exogenous substrate. Evidence was obtained for an increased Ca-dependent proteolytic activity in lymphocytes from patients with early onset Alzheimer's disease. There was also an increased level of membrane-bound mu-calpain in this group of patients. The observed changes may be caused by a general dysregulation of Ca homeostasis in peripheral cells of early onset Alzheimer victims.

Age of Onset↗