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Biomedical subjects

I K Drainer

Publications and source records attributed to I K Drainer.

14 recordsLinked to original sources
PubMed1993

Continent urinary diversion using Mitrofanoff principle in children with neurogenic bladder.

Fifteen children with urinary incontinence underwent continent urinary diversion using Mitrofanoff principle between April 1990 and March 1993, at a mean age of 14 years. Neurogenic bladder was the main underlying cause of incontinence and spina bifida accounted for the majority of cases (12 patients). Reversed vascularised appendix was used as a cutaneous stoma for intermittent self-catheterisation Fourteen out of the fifteen children treated, achieved urinary continence with 3-4 hourly catheterisation.

Adolescent↗
PubMed1987

Congenital anal anomalies in two families with the Opitz G syndrome.

Five children from two families presented to a regional neonatal surgical unit between 1959 and 1984 with congenital anal anomalies and other malformations resulting from an autosomal dominant inherited condition, the Opitz G syndrome. This and other Mendelian causes of congenital anal malformations are briefly discussed in view of their importance for genetic counselling.

Abnormalities, Multiple↗
PubMed1986

The role of prostaglandins E2 and F2 alpha in infantile hypertrophic pyloric stenosis.

Endogenous prostaglandins (PGs) have been isolated in large amounts from the gastrointestinal tract of man. These substances are intimately related to muscle contraction and cytoprotection. The gastric juice and serum levels of PGE2 and F2 alpha have been assayed in nine infants with infantile hypertrophic pyloric stenosis (IHPS) and seven age-matched controls. The gastric juice levels were significantly raised in the IHPS group for both PGE2 (P = 0.001) and PGF2 alpha (P = 0.02) as compared to controls. The possible role of PGs in the etiology of IHPS is discussed.

Dinoprost↗
PubMed1985

Pierre Robin syndrome and pulmonary hypertension.

Five infants with Pierre Robin syndrome developed evidence of carbon dioxide retention and congestive cardiac failure despite measures to alleviate upper airway obstruction. Investigations included chest radiography, electrocardiography, echocardiography, and cardiac catheterization; pulmonary hypertension was diagnosed. In two cases raised main pulmonary artery pressures of 40 mm Hg and 120 mm Hg were recorded. Relief of upper airway obstruction was achieved by tracheostomy in three cases and nasopharyngeal intubation in two cases, with reversal of signs of cor pulmonale in each. Four patients progressed well with no recurrence of cardiac problems but one died suddenly one month after apparently successful management by tracheostomy.

Female↗
PubMed1984

A simple method of assessing intracranial pressure in hydrocephalic patients with shunts.

A simple method is described for assessing intracranial pressure in patients with Holter valves when the function is questionable. The method entails measuring intravalvular pressure by puncturing the valve belly with a fine needle connected to a manometer. High pressure suggests a distal occlusion; very low pressure coupled with difficulty in aspirating CSF suggests a proximal occlusion. All pressures have to be corrected by the addition of a factor equal to half the pressure specification of the valve. The results of a pilot study support these conclusions.

Adolescent↗
PubMed1983

Minor burn injuries in children: inpatient versus outpatient treatment?

Seventy-two children with minor superficial burns presented at our casualty department over a 5-month period. Half were treated as inpatients and the other half as outpatients. The colonisation rates were similar in the two groups. Colonised and sterile burns treated as inpatients showed no significant difference in healing rates. The healing time, however, was prolonged in colonised outpatient treated burns. Cosmetic results were satisfactory overall. In the absence of a definite benefit from inpatient treatment, outpatient care of a child with a minor burn should therefore be used if circumstances allow.

Burns↗
PubMed1979

Serum cholecystokinin, basal acid secretion, and infantile pyloric stenosis.

The fasting serum cholecystokinin-like activity was measured in 21 infants with pyloric stenosis and in 13 normal controls. No significant difference was found between the two groups. The basal acid secretion was measured by continuously aspirating the previously emptied stomach for one hour. The basal gastric volume and the total and the free acidity were all greater in the pyloric group.

Cholecystokinin↗
PubMed1976

Congenital hypertrophic pyloric stenosis: A gastrin hypothesis pursued.

Pentagastrin and acetyl choline were shown to contract isolated strips of the circular pyloric muscle from baboons. These findings are compatible with the hypothesis that gastrin may have a part to play in the development or maintenance of congenital hypertrophiic pyloric stenosis of infancy.

Acetylcholine↗
PubMed1975

Plasma gastrin in congenitial hypertrophic pyloric stenosis. A hypothesis disproved.

Fasting plasma gastrin levels were measured in babies with pyloric stenosis and in normal babies of similar age. There was no difference in gastrin levels either before or after operation between the babies with pyloric stenosis and normal babies. Similarly, neither the fasting blood glucose nor the fasting gastric pH of the babies with pyloric stenosis differed significantly from the values obtained in normal babies. Our findings do not support the hypothesis that gastrin in the fasting baby has an aetiological role in the development of hypertrophic pyloric stenosis of infancy. An alternative hypothesis is suggested.

Animals↗