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Biomedical subjects

I K Stone

Publications and source records attributed to I K Stone.

7 recordsLinked to original sources
PubMed1990

Serum lipids and lipoproteins in continuous or cyclic medroxyprogesterone acetate treatment in postmenopausal women treated with conjugated estrogens.

This study evaluates effects on serum lipids of continuous or sequential progestogens for hormonal replacement in women. Subjects received either a cyclic regimen of replacement (0.625 mg/d of conjugated equine estrogens (Es) for 25 days/month and 10 mg medroxyprogesterone acetate [MPA] for the last 13 days of E) or 0.625 mg/d E along with either 5 or 10 mg MPA (Provera, Upjohn Company, Kalamazoo, MI). Study parameters were measured over a 24-week period. No differences in total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, apolipoproteins I and II, sex hormone-binding globulin, or serum MPA levels were noted between the sequential and 5 mg continuous group. The 10 mg MPA group did not have an increase in HDL or decrease in low-density lipoprotein as did the other groups.

Adult↗
PubMed1988

Suture materials.

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Absorption↗
PubMed1987

The use of nylon pouches to prevent cellular attachment to implanted materials.

A nylon pouch system has been developed to permit the in vivo exposure of implantable materials to tissue fluids without complications arising from cellular attachment or from the bacterial attack. SEM observations have indicated that the pouches were effective in reducing the ingress of bacteria as well as reducing, and in some cases eliminating, cell infiltration through their mesh structure. Over a 7 d implantation period, the exterior surfaces of the nylon pouches were heavily infested with microorganisms but there was minimal growth of bacteria within the pouches. Non-infected pouches that were implanted for up to 25 wk showed heavy deposits of cellular matter on the external surfaces of the pouches and minimal deposits within the pouches.

Absorption↗
PubMed1986

The biomechanical effects of tight suture closure upon fascia.

The biomechanical effect of tight suture closure of fascial incisions in male rats was evaluated. The incision of rats in group 1 was closed with maximum tension on the first throw of the approximating knot. The incision of rats in group 2 was closed in a similar manner, however a 3.14 squared millimeter rod was placed in the suture loop before securing the first throw. The rod was removed after the knot was formed and fascial edges were observed to be loosely approximated. All rats were sacrificed after seven days. The abdominal fascial and muscle unit was dissected and a 1 by 6 centimeter strip containing two suture loops was excised. Scanning electron microscopic examination of tissue specimens, tensile strength measurements and energy-to-failure under tensile loading studies were performed. Specimens for hydroxyproline assay were obtained from the tissue immediately surrounding the incision and between two suture loops. The scanning electron microphotographs of group 1 showed tissue overlap from the excessive force on the initial knot throws. Wounds loosely approximated had proper alignment of the wound edges and had greater proliferative activity in the clefts of the wounds. The tensile strength and energy-to-failure studies showed loosely approximated wounds to be far stronger (p less than 0.001). No statistically significant difference (p greater than 0.05) was found between hydroxyproline assays of the two groups.

Animals↗
PubMed1985

A comparative study of suture materials: chromic gut and chromic gut treated with glycerin.

Histologic and mechanical properties of chromic gut and glycerin-treated chromic gut were evaluated. Zero gauges of both materials were implanted for 7 days to evaluate inflammatory response. No difference was found in the degree of inflammatory response. Scanning electron micrographs showed a more uniform surface for the glycerin-treated chromic gut. Regular chromic material was stronger in unknotted tensile strength and fracture load for all gauges. The 1-0 gauge glycerin-treated chromic gut stabilized with the knot configuration of 1 = 1 = 1 = 1; and the 1,2-0, and 3-0 gauges reached knot security at 1 = 1 = 1. The in vivo studies showed marked difference in the tensile strength of stable knots between the two materials. Only with five throws (1 = 1 = 1 = 1 = 1) did the strength of glycerin-treated chromic gut overlap that of regular chromic gut.

Animals↗