Biomedical subjects
Publications and source records attributed to I Kan.
Primary biliary cirrhosis is often associated with autoimmune conditions, such as thyroid disease, sicca complex, and rheumatoid arthritis. However, an association with autoimmune hemolytic anemia has rarely been reported. We present a case of primary biliary cirrhosis associated with warm type autoimmune hemolytic anemia, and we review prior reports.
A 47-year-old male with pseudoaneurysm of the left ventricle secondary to mitral valve replacement was herein reported because of its unique etiology. The pseudoaneurysm was presumably resulted from the mitral valve dilator wound at the apex of the left ventricle, which was produced by closed mitral commissurotomy 23 years ago. To our knowledge, it seems to be a rare reported case with pseudoaneurysm of the left ventricle caused by closed transventricular mitral commissurotomy.
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A cytogenetic study of unsuccessfully fertilized oocytes was done for information on the frequency and type of chromosomal abnormalities leading to preimplantation loss. Of 72 oocytes, 44 were assessed as mature, 19 as intermediate, and 9 as immature. The mean fertilization rate was 68%. This rate was significantly lower in immature oocytes than in mature ones (22% versus 79%). Immature oocytes completed maturation in vitro up to metaphase II of meiosis. Intermediate oocytes became fertilizable, however, a significant proportion showed morphologic abnormalities after fertilization. Thus, eggs with three pronuclei were hypotriploid or had three prophasic chromosome sets, together with polyspermy and with first polar body chromosomes. Eggs with developmental arrest showed marked asynchrony in pronuclear morphogenesis. One had a chromosome complement of 24,XX. It is concluded that insemination prior to completion of maturation leads to abnormal development.