[Extensive resection of the small intestine following mesenteric embolism].
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Biomedical subjects
Publications and source records attributed to I Kausz.
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In patients with intestinal obstruction, nine of the enzymes usually studied in liver diagnostics were determined before and after operation. Intestinal obstruction causes reversible changes in the liver and in hepatic metabolism; they normalize after relief of the obstruction.
After inducing experimental ileus in albino rats, the authors found changed lysosome enzyme activities in liver homogenizate. In the same kind "free" activity of acid phosphatase and acid ribonuclease is elevated by strangulation ileus. According to literature, these alterations result from changed permeability of lysosome membranes, resp. from rupture of lysosomes. Ileus by obstruction causes no significant changes of the "free" lysosomes activities in liver homogenizate. Increase of acid phosphatase and ribonuclease in blood serum by strangulation or obstruction is equally considerable in both kinds of ileus. The results of these experiments suggest the developing of hepatic damage under both kinds of experimental ileus, the extent of which can be assessed by determination of lysosome enzyme activities.
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