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Biomedical subjects

I Keil

Publications and source records attributed to I Keil.

13 recordsLinked to original sources
PubMed1989

[Retrospective studies of the long-term course of various forms of hyperthyroidism with special reference to prognostic aspects].

In 153 patients, who from 1978 to 1982 were under treatment for clinically and radiochemically proven hyperthyroidism, thyroid function was re-examined at an observation interval of 5-10 years. Overall, the remission rate after initial treatment was 75%; after 5-10 years, 123 patients (80%) showed an euthyroid metabolic condition. Following conservative therapy alone, euthyroidism was seen unexpectedly often in patients with supposed autonomy. This is probably due to a transitory iodine contamination and a heterogeneous case material, as the differentiation from Basedow's hyperthyroidism may be difficult. The conservative initial therapy with thyrostatic drugs is indicated for both forms of hyperthyroidism. Based on the hitherto known prognostic criteria, a reliable prediction of the clinical course of a given case cannot be provided.

Adenoma↗
PubMed1988

[Thyroid diseases in advanced age].

Nearly all diseases of the thyroid, such as nodular goitre, thyroid carcinoma, non-immunogenic hyperthyroidism and idiopathic hypothyroidism, exhibit an increase in frequency with age. Their recognition is rendered more difficult by the often oligosymptomatic, ambiguous clinical picture, but it is the timely treatment that is of particular prognostic importance to an organism weakened due to polymorbidity. In all hard nodular alterations, a malignoma must be ruled out by sonography, scintigraphy and cytopuncture. In all iodine-deficient regions such as the GDR, a frequent occurrence of thyroid autonomy with manifestation of hyperthyroidism following iodine contamination has to be taken into account. Hypothyroidism is often misinterpreted as age-related changes. By employing adequately modern in vitro methods and imaging procedures it will be possible to further improve diagnosis and prognosis of the thyreopathy in the old age ranges.

Aged↗
PubMed1986

[Myxedema coma].

Explore the source record for details and available documents.

Coma↗
PubMed1984

[Course studies in patients with cytologically inconspicuous, decreasingly accumulating struma nodes].

In 100 patients with inconspicuous findings of a thin-needle puncture of the thyroid gland after 2 years a clinical and cytological after-examination was performed. All test persons were primarily recommended a treatment with thyroid hormone. During the control in no case references to malignant process of the thyroid gland were the result, so that the puncture cytology also retrospectively showed a high exactness. Meanwhile 16 test persons had been strumectomized, in which cases the present histological findings always showed only regressive changes. The clinical after-examination confirmed former results so that also in decreasingly and not accumulating struma nodes a conservative approach is not promising a success. In 12 patients by application of hormones of the thyroid gland the struma had completely receded.

Biopsy, Needle↗
PubMed1982

[Thyroid autoantibodies in diabetes mellitus and rheumatoid arthritis].

In 58 patients with rheumatoid arthritis and 101 patients with diabetes mellitus (type I) microsomal antibodies of the thyroid gland as well as antinuclear factors were determined and their frequency was compared with the frequency in test persons with hyperthyroidism, bland struma and a control group. Only in diabetes mellitus with 13% an increased presence of humoral sensitization of the thyroid gland was found, whereas relevant to this no considerable differences were present between rheumatoid arthritis (5%), bland struma (5%) and controls (4%). As we expected the frequency of antibodies was high with 74% in the diffuse hyperthyroidism. In patients with rheumatism antinuclear factors were increasedly found only in higher degrees of titres. Though the determination of microsomal autoantibodies is only one parameter in the immunological diagnosis of the thyroid gland, it seems that according to our investigations a Hashimoto-thyroidism in rheumatoid arthritis does not increasedly occur. Overlapping immune reactions were found only among presumable autoimmunoendocrinopathies. The thesis of the preferred combination of autoimmune sensitization among the groups with organ-specific or organ-unspecific antigens is supported according to the present findings. The insignificant appearance of thyroid autoantibodies in the bland struma refers to the fact that in the endemic area immunomechanisms play an inferior role for the development of struma.

Antibodies, Antinuclear↗
PubMed1979

[Drug follow-up therapy after resection of hyperthyroid struma].

By means of a hormone prophylaxis the number of recidivations after the operation of a hyperthyreotic struma could be decreased from 40% to 11%. Recidivations appeared exclusively in doses of equivalency below 50 microgram triiodine thyronine/die. Their number was four times larger, when the hormone prophylaxis was begun only weeks to months after operation. The tendency to neglect the prophylaxis which becomes clearer with the time renders a strong leading by the physician necessary.

Drug Therapy, Combination↗
PubMed1975

[Cell-mediated immune-phenomenona in hyperthyroidism and euthyroid goiter (studies using the lymphocyte transformation test)].

For the establishment of cellular immune phenomena in hyperthyroidism and the euthyreotic struma 27 patients with hyperthyroidism, 18 patients with euthyreotic struma and 33 healthy control persons were examined with the help of the lymphocyte transformation test as to their ability to the blast cell transformation under addition of watery extract of the thyroid gland. In the cases of hyperthyroidism significantly increased transformation indices were found compared with the controls. Also in the euthyreotic strumae increased values were found compared with the controls. They lay at the borderline to significance. Three different extracts were used as antigen. The transformation indices calculated in these cases were partly significantly different. From this is concluded that not in every watery extract of the thyroid gland the responsible antigen exists in sufficient quantity and/or quality.

Antibody Formation↗