In an exhaustive retrospective study of splenic trauma diagnosed over a 7-year period (1986-1992) in our orthopaedic trauma centre we collected 63 cases. Splenectomy was performed in 25 patients, conservative surgery was performed in 6 and non-surgical conservative therapy was possible in 32. The large percentage of non-surgical cases was possible due to the simple clinical course in cases diagnosed late and because of careful surveillance and the precision of scanographic diagnosis. The concept of conservative non-surgical treatment appears to be validated by the lack of mortality and the high success rate (only 3 failures out of 32) in our unselected population which included polytrauma cases and patients of all ages and all types of splenic lesions. Nevertheless, shock resulting from splenic injury. In cases where bleeding is the sign of non-surgical treatment failure and in cases with acquired or induced coagulopathy and a pathological spleen, splenectomy is also indicated. Our results indicate that, when scanographic diagnosis is permanently available and when clinical surveillance is adequate, conservative non-surgical treatment can be proposed in patients with a stable haemodynamic status.

Adult↗

PubMedDate not supplied

Dose titration study of enrofloxacin (Baytril) against respiratory colibacillosis in Muscovy ducks.

Four-week-old specific-pathogen-free Muscovy ducks were inoculated with reovirus. One week later, they were inoculated intratracheally with a O78:K80 strain of Escherichia coli. The next day, they were given enrofloxacin at different doses in the drinking water. Comparison of mortality rates, weight gain, macroscopic lesions, and E. coli re-isolations among treated and untreated birds showed that a 5-day treatment course with 12.5 or 25 ppm enrofloxacin in water for 4 hours in the morning provided good therapeutic efficacy against respiratory colibacillosis.

Animals↗

PubMedDate not supplied

[Our present attitude concerning the treatment of closed leg fractures].

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Fracture Fixation, Internal↗

PubMedDate not supplied

Efficacy of tilmicosin in the control of experimental Mycoplasma gallisepticum infection in chickens.

This study was conducted to evaluate the efficacy of 5-day, "in water" tilmicosin medication for the prevention of experimental Mycoplasma gallisepticum (MG) disease in 10-day-old specific-pathogen-free (SPF) chickens. Birds were inoculated intratracheally and into the sinus with the MG R-P10 strain. A limited dose titration of the antibiotic over the expected effective range was included, using six groups of 60 birds each: UI: uninfected untreated group; IUT: infected untreated group; IT1 to IT4: four infected treated groups, which were administered 50, 100, 200, or 300 mg/liter of tilmicosin. The birds were given tilmicosin from 8 to 13 days of age and were inoculated at 10 days of age. The birds were observed for 11 days postchallenge before terminal postmortem examination was completed including, assessment of lesions and sampling for mycoplasma culture and serology. Body-weight gains of the different groups were compared. The results showed that tilmicosin medication at dose levels of 50-300 mg/liter significantly decreased growth losses and respiratory signs due to MG infection (P < 0.05). Significant reduction in air sac and peritonitis lesions were obtained by treatment with 100, 200 or 300 mg/liter for 5 days (P < 0.05). A significant reduction in the proportion of MG-culture-positive birds was obtained at a dose level of 50 mg/liter (P < 0.05). Increasing the dose resulted in a further decrease in the number of MG shedding chickens to the extent that with the two highest doses of tilmicosin, no bird was serologically positive on day 21, compared to 46/58 positively infected untreated birds (day 21).

Administration, Oral↗