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Biomedical subjects

I Kimmel

Publications and source records attributed to I Kimmel.

4 recordsLinked to original sources

Differences in the attitudes of couples whose children were conceived through artificial insemination by donor in 1980 and in 1996.

OBJECTIVE: To compare the attitudes of couples whose children were conceived through artificial insemination by donor (AID) in 1980 and in 1996. DESIGN: Replication study. SETTING: Infertility clinic of the Utrecht university hospital. PATIENT(S): Couples who conceived a child through AID in 1980 (n = 134) or in 1996 (n = 110). INTERVENTION(S): Anonymous questionnaires. MAIN OUTCOME MEASURE(S): Answers to questionnaires. RESULT(S): Couples who conceive a child through AID still strongly prefer (84%) absolute anonymity of the donor. In both 1980 and 1996, most couples (approximately 80%) decided not to inform their child about the nature of his or her conception. In 1996, couples who considered informing their child hesitated significantly less and showed significantly more openness toward others. In addition, more couples wanted unidentifiable data about the donor and considered it more important to use the same donor for a subsequent child. CONCLUSION(S): Between 1980 and 1996, the number of couples who conceived a child through AID and adhered to absolute anonymity of the donor and secrecy toward the child remained the same, whereas their openness toward others and desire for unidentifiable data about the donor increased.

Attitude↗

The dual-system hypothesis of pain perception.

We describe a dual-system hypothesis relating the seemingly contradictory findings reported in clinical and experimental investigations of pain. This incorporates a model in which two neuronal systems are related, involving Substance P (SP) and Enkephalin (E). This model uses feedback loops holding the systems in balance. The analogy to a control system is also made.

Animals↗

Stereochemical requirements for cannabinoid activity.

Several pairs of cannabinoid isomers were synthesized and tested for psychotropic activity in rhesus monkeys. Two regularities were observed: (a) In the absence of the other substituents, the equatorial stereochemistry of the substituent at C-1 determines activity. (b) Two groups of THC-type cannabinoids which differ only in that the chemical groupings in one of them at C-1, C-2 are situated at C-1, C-6 in the other (but retain their stereochemistry) have almost equivalent psychotropic activity.

Animals↗