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I Klemm

Publications and source records attributed to I Klemm.

3 recordsLinked to original sources
PubMed1993

Experimental enteritis produced by high environmental temperature.

The authors exposed groups of Wistar rats of different average body weight to elevated environmental temperature. Necrotizing enteritis-like changes developed in the majority (up to 85%) of the animals. The best results were found in the group treated for 20 minutes at 45 degrees C, 20 minutes at rest, and 20 minutes at 56 degrees C. Subnuclear vacuolization of the enterocytes on the top of the villi intestinalis seems to be the initial event followed by subepithelial cleft formation, lifting and shedding of the epithelial cells, infiltration of the stroma by active phagocytes, and autolysis. Changes of the mesenteric blood flow can play a crucial role in the development of these lesions.

Animals↗
PubMed1992

The effects of local hyperthermia on the morphology of the small bowel.

Intestinal lesions were produced experimentally by heating the eventrated loop of the small intestine of Wistar rats in 44 degrees C 0.9% saline 20 minutes. Luminal haemorrhage and elevation of the potassium concentration in the wash-out fluid were registered from the fifth minute of the experiment. In the sediment of the wash-out fluid erythrocytes, degenerated and necrotic epithelial cell clusters were found. Histologically the mildest lesions were subnuclear vacuolization of the epithelial cells and stromal oedema of the villi. In the medium-degree lesion subepithelial cleft formation, desquamation of the epithelial cells and denudation of the villi occurred. The fully developed lesion was characterized by the destruction of the villi intestinalis and haemorrhage. This lesion produced by local heating differs from the intestinal lesions of the rats exposed to high environmental temperature basically in the haemorrhagical nature of the former lesion.

Animals↗