PubMed Health⌕ Search

Biomedical subjects

I Kranjec

Publications and source records attributed to I Kranjec.

12 recordsLinked to original sources
PubMed2000

Mildly elevated serum creatinine concentration correlates with the extent of coronary atherosclerosis.

Mildly elevated serum creatinine concentration was proposed to be a marker for increased risk of cardiovascular disease mortality. The aim of our prospective study was to evaluate a possible association between serum creatinine concentration and extent of coronary atherosclerosis together with conventional risk factors for atherosclerosis. Serum creatinine concentration was measured in 40 male patients without overt renal or ischemic renal disease (mean age 53 +/- 7 years) with stable or unstable angina undergoing routine coronary arteriography. The extent of coronary atherosclerosis was assessed by Gensini score. In univariate linear regression analysis Gensini score significantly correlated with serum concentrations of apolipoprotein AII (r=-0.3242, P<0.05) and creatinine (r=+0.3194, P<0.05), but not with serum concentrations of lipids (total, low- and high-density lipoprotein cholesterol, triglycerides), other apolipoproteins (apo B, apo AI), lipoprotein(a), autoantibodies to oxidatively modified low-density lipoprotein or age, weight and status of smoking, diabetes or hypertension. Multivariate linear regression analysis revealed that elevated serum creatinine was associated with the extent of coronary atherosclerosis independently of conventional risk factors for atherosclerosis. Mildly elevated serum creatinine was probably the marker of generalised vascular disease denoting early nephrovasculopathy in correlation with established atherosclerotic risk factors.

Cardiac Catheterization↗
PubMed2000

Vascular complications after percutaneous coronary interventions using abciximab (Reopro ): prospective evaluation with Doppler color flow imaging.

UNLABELLED: The aim of our study was to assess the incidence and consequences of vascular access site complications (VASC) associated with abciximab treatment in patients undergoing percutaneous transluminal coronary angioplasty (PTCA). PATIENTS AND METHODS: Between July 1996 and November 1997, 120 patients underwent PTCA with adjunctive abciximab (n = 60) or without it (n = 60). VASC were assessed within 24 hours of PTCA completion by physical examination and Doppler color flow imaging (DCFI) of the groin. RESULTS: A total of 24 VASC were observed mostly in abciximab patients (30% vs. 10%; p = 0.006) and only half of them were suspected on physical examination. Abciximab administration [odds ratio (OR) = 3.1; 95% confidence interval (CI) = 1.03Eth 9.0; p = 0.001], platelet fall > 40% (OR = 5.0; CI = 1. 03Eth 24.6; p = 0.045), and double-wall femoral artery puncture (OR = 5.3; CI = 1.9Eth 14.7; p = 0.001) carried a high probability of VASC after multivariate analysis. Vascular repair was needed in 10% of abciximab patients. CONCLUSIONS: Aggressive antiplatelet drugs adjunctive to the anticoagulation treatment may result in an increased rate of VASC after PTCA. The use of refined catheterization techniques is advised to avoid VASC associated with abciximab administration. DCFI is recommended in the patients with abnormal groin finding or significant platelet fall after PTCA.

Abciximab↗
PubMed1991

Primary malignant pericardial mesothelioma.

Malignant primary tumors of the pericardium are rare. The authors present two male patients, aged 44 and 67 years, not exposed to asbestos, who died from pericardial mesothelioma. Repeated evacuation of fluid from the pericardium due to cardiac tamponade failed to reveal the cause of pericarditis. In one case, the diagnosis was made on surgical exploration, and in the other, at autopsy. A significant difference between benign and malignant pericardial effusion was observed. In cases of pericardial mesothelioma, symptoms of epicardial involvement cannot be attributed solely to the hindered inflow and cardiac tamponade, but also to congestive heart failure due to myocardial infiltration. In one patient, temporary improvement was achieved, first by pronisone therapy and then by radiotherapy.

Adult↗
PubMed1987

Angiographic morphology and intraluminal coronary artery thrombus in patients with angina pectoris: clinical correlations.

A prospective study was conducted in 104 consecutive patients who underwent coronary angiography for the evaluation of angina pectoris. 50 patients experienced unstable symptoms, while the rest of them were stable. Coronary lesions reducing the luminal diameter by at least 50% were compared between both groups according to localization, grade, length, type and collateralization. Eccentric irregular lesions (EIL) appeared more frequently in the unstable group of patients (27% vs 3%, P less than 0.01), while the incidence of concentric lesions was higher in stable group (45% vs 26%, P less than 0.02). There was no significant difference in localization, grade, length, or collateralization. EIL were most frequently identified as spontaneous AP producing lesions (55%, P less than 0.001) in 29 patients in the unstable group. Spontaneous angina was associated in 86% with EIL, occlusions, or filling defects--all of these lesions might contain occlusive or nonocclusive thrombi. EIL with a narrow neck appeared on angiograms earlier than EIL with a wall irregularity. We conclude that EIL is a sensitive and very specific angiographic marker of unstable AP. The morphologic details of EIL may help one to choose appropriate therapy.

Angina Pectoris↗
PubMed1987

Pericardial mesothelioma.

The case of a 44-year old man, never exposed to asbestos, who died from a pericardial mesothelioma is described. The diagnosis was made by surgical examination. Two weak transient episodes of amelioration, the first accomplished with pronison administration and the other one by radiotherapy, were registered.

Adult↗
PubMed1986

Detection of electrocardiographically imperceptible ventricular pre-excitation by phase imaging.

The sequence of ventricular contraction was studied by radionuclide phase imaging in 25 patients with Wolff-Parkinson-White syndrome. The studies were performed when no signs of precontraction were present in the electrocardiogram; in these cases pre-excitation was either intermittent or suppressable by injection of ajmaline. In 11 of the 16 patients with free wall accessory pathways, precontraction could be detected in spite of electrocardiographically absent pre-excitation. Discrete precontraction was seen also in 2 of the 9 patients with paraseptal accessory pathways. We conclude that antegrade conduction through the accessory pathway does not need to be completely blocked if signs of pre-excitation are absent on the electrocardiogram, and that phase imaging is, at least in some patients (especially those with free wall accessory pathways), a more sensitive technique for detection of pre-excitation (precontraction) than the electrocardiogram.

Electrocardiography↗
PubMed1985

Wolff-Parkinson-White syndrome type B and left bundle-branch block: electrophysiologic and radionuclide study.

Coinciding left bundle-branch block and Wolff-Parkinson-White syndrome type B, a very rare electrocardiographic occurrence, was found in a patient with dilated cardiomyopathy. Electrophysiologic study revealed eccentric retrograde atrial activation during ventricular pacing, suggesting right-sided accessory pathway. At programmed atrial pacing, effective refractory period of the accessory pathway was 310 ms; at shorter pacing coupling intervals, normal atrioventricular conduction with left bundle-branch block was seen. Left bundle-branch block was seen also with His bundle pacing. Radionuclide phase imaging demonstrated right ventricular phase advance and left ventricular phase delay; both right and left ventricular phase images revealed broad phase distribution histograms. Combined electrophysiologic and radionuclide investigations are useful to disclose complex conduction abnormalities and their mechanical correlates.

Aged↗
PubMed1985

Association of an accessory atrioventricular pathway and ipsilateral bundle branch block.

We performed electrophysiological study and radionuclide phase imaging in a patient with intermittent Wolff-Parkinson-White syndrome type A and left bundle branch block. The presence of a left-sided accessory pathway was proven by eccentric retrograde atrial activation. Phase-imaging revealed delayed left ventricular phase angles when left bundle branch block was present in the electrocardiogram. There was an advance of early phase angles at the ventricular insertion of the accessory pathway as well as delayed phase angles in the rest of the left ventricle when the pre-excitation pattern was seen electrocardiographically.

Atrioventricular Node↗
PubMed1985

Multiple accessory pathways: a combined electrophysiological and radionuclide study.

Electrophysiological study in a patient with Wolff-Parkinson-White syndrome revealed multiple accessory pathways: Kent bundle and Mahaim nodoventricular and fasciculoventricular fibers. Radionuclide phase imaging disclosed two distinct ventricular activation sequences during sinus rhythm or slow atrial pacing and during fast atrial pacing. The third activation pattern could be recorded after injection of ajmaline, which abolished signs of preexcitation in the electrocardiogram. Phase image in combination with pacing and pharmacological interventions can, at least in some cases, detect complex preexcitation syndromes noninvasively.

Adult↗
PubMed1983

Localization of accessory pathways in Wolff-Parkinson-White syndrome by phase imaging.

Phase image analysis of blood pool scintigrams was performed in 6 patients with Wolff-Parkinson-White (WPW) syndrome to determine the relationship of phase changes and abnormalities of atrioventricular conduction. The site of preexcitation was located by invasive endocardial mapping. The phase advance generally correlated with the electrophysiologically determined location of the accessory pathway. Factors which increase or decrease the amount of preexcitation also increased or decreased the advance of mean phase angles. Phase imaging is a useful noninvasive means for tentative location of accessory pathways in WPW syndrome.

Adolescent↗
PubMed1982

Induced concealed dissimilar atrial rhythms.

Electrophysiologic studies, including intra-atrial recordings and atrial stimulation, were performed in two patients with suspected sick sinus syndrome. Premature atrial stimuli induced atrial flutter in both patients. The arrhythmia was concealed, i.e., it was recordable only by intracavitary electrogram and invisible on surface electrocardiogram. In one case, simultaneous atrial fibrillation could be recorded in a segment of the right atrium. In this patient, the rhythm on the surface electrocardiogram changed during the study to "upper nodal" rhythm, though the atrial electrogram showed continuation of A waves at the same rate as before during sinus rhythm. It seems that atrial changes, which are frequently encountered in sick sinus syndrome, are a predisposing factor for spontaneous or inducible concealed atrial arrhythmias.

Atrial Flutter↗