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Biomedical subjects

I Krc

Publications and source records attributed to I Krc.

At least 19 recordsLinked to original sources
PubMed1992

Immunohistochemical determination of some tumour markers (blood group antigens A, B, H, T-antigen, CEA) in colonic and rectal tissue after endoscopic polypectomy.

The expression of blood group antigens A, B, H, T-antigen and CEA was determined in tissue samples of polyps of the rectosigmoideum removed by endoscopic polypectomy. On average 39 months later, during colonoscopic examination bioptic samples were removed at the site of previous polypectomy and the expression of the same tumour markers as previously was determined. In contrast to literary data, the cellular expression of blood group antigens was demonstrated only in one case out of seven adenomas of the rectosigmoideum. On the other hand, cellular expression of blood group antigen B was found in 6 cases at the site of previous polypectomy and in 6 cases, this antigen was incompatible. Interpretation of these results is difficult at this time.

ABO Blood-Group System↗
PubMed1992

Secondary Hodgkin's disease in polymyositis and type 1 diabetes mellitus after a long-term immunosuppressive treatment.

Immunological disorders can play an important role in the etiopathogenesis of malignant lymphogranuloma. The authors demonstrate a patient with autoimmune polymorbidity (polymyositis and type 1 diabetes mellitus) which underwent a long-term immunosuppressive and cytostatic therapy. After 7 years of that treatment, Hodgkin's disease of mixed cellularity type developed. The clinical findings of the case are described and the clinical particularities along with possible mutual links among these diseases are stressed.

Dermatomyositis↗
PubMed1992

[Asymptomatic HBs antigenemia in pregnant women].

The authors have dispensarized for more than ten years HBsAg carriers at the Second Medical Clinic of the Olomouc Faculty Hospital when antigenaemia was detected during blood donorship. Since 1990 the authors dispensarize also women where HBs antigenaemia was revealed during pregnancy. In the presented paper the authors analyze this group of women. In 1990-1991 the authors examined blood samples for HBsAg from 12,042 symptom-free pregnant women. HBsAg positivity was proved in 34 women (0.28%). Eleven women (32.3%) are regularly followed up since delivery. The authors know nothing about the fate of 10 women (29.4%), as they did not respond to repeated invitations to the surgery. It must be however mentioned that 6 of them are Vietnamese and probably left Czechoslovakia. Four women (11.7%) did not attend the clinic for examination but the authors know that they were delivered of their babies elsewhere. In the remainder, i.e. 8 women the delivery was normal, usually in term. The neonates were passively as well as actively immunized at the appropriate dates. Their umbilical blood (if collected) was HBsAg positive, while the venous blood was in all instances negative. All 20 women who attended examination were throughly examined (ultrasound, HBeAg, HBeAb etc.) and the clinical picture is that of a "healthy" HBsAg carrier (not verified by histological examination).

Carrier State↗
PubMed1991

L-asparaginase--a reassessment.

The authors review some historical data connected with the discovery of the enzyme l-asparaginase and then summarize the basic informations concerning the mechanism of action, clinical application, toxicity and future prospectives of this substance. From the clinical viewpoint, a broader use of l-asparaginase prepared from Erwinia carotovora instead of Escherichia coli seems to be warranted.

Asparaginase↗
PubMed1991

Malignant lymphoma involving the heart.

In a group of 116 patients with different types of malignant lymphoma, the frequency, type and clinical manifestations of heart involvement are evaluated. A case of primary cardiac lymphoma is demonstrated. Along with this, clinical and pathological findings in 15 further subjects with secondary lymphomatous infiltration of the heart are discussed; attention is being paid also to indirect factors causing cardiovascular damage, including radio- and chemotherapy.

Female↗
PubMed1991

The features of hypertrophic osteoarthropathy.

Features of 10 patients with hypertrophic osteoarthropathy are described. Seven patients suffered from lung disease. Joint symptoms preceded the symptoms of primary disease in four cases. Symmetrical periosteal new bone formation was present in all patients. The theories of hypertrophic osteoarthropathy pathogenesis are discussed.

Adolescent↗
PubMed1991

Bleeding to the adrenal gland as a terminal manifestation of acute leukaemia.

The authors refer about an unusual localization of haemorrhage to the adrenal glands, observed in two patients with acute leukaemia similar to the picture of Waterhouse-Friderichsen's syndrome. This complication causing serious and dramatic effects should be taken into differential diagnostic consideration. Literature data and own results are given in order to review the general characteristics of bleeding in acute leukaemia.

Acute Disease↗
PubMed1990

Bone marrow necrosis intravitally recognized in four cases of blastic leukaemia.

Bone marrow necrosis (BMN) is a rare intravitally recognized finding in acute leukaemia with an uncertain clinical significance. The clinical events in 4 patients with AML, ALL, AMoL and blastic transformation of CGL in whom bone marrow cytology and histology revealed BMN are reviewed. One patient with BMN at clinical presentation of AML entered complete, long lasting remission with marrow restoration after the standard DAT therapy. In the three remaining patients survival after BMN diagnosis was 6, 11, and 14 weeks. Clinical, haematological, histological and marrow scanning findings and their significance for early diagnosis and means to asses the extent and evaluation of BMN will be discussed. In contrast to the most earlier reports, BMN does not appear to confer a poor prognosis in all patients with blastic leukaemia.

Acute Disease↗
PubMed1990

Bleeding complications in chronic lymphocytic leukaemia.

In a series of 164 patients, a retrospective study has been carried out on the incidence, frequency and character of bleeding episodes occurring in chronic lymphocytic leukaemia. The authors stress the relatively high frequency of haemorrhagic complications which were causing death in a significant proportion of cases (5.5%). Thrombocytopenia was the main precipitating factor of bleeding on most occasions.

Hemorrhage↗
PubMed1990

Balloon cell melanoma of the skin. part I: Histology, immunohistology and histochemistry.

Balloon cell melanoma of the skin was found in the left axillary region of a 60-year-old man. The tumour was very large, grew local, not forming metastases. The histological picture corresponded to a solid alveolar pattern, in some places with pseudoglandular structures. The cytoplasm of the balloon cells proved to contain lipid vacuoles and glycogen. The Masson-Fontana reaction was negative: the Warthin-Starry method gave positive results in sporadic tumour cells. The DOPA oxidase reaction was negative. Histochemistry demonstrated remarkable presence of histiocytic elements among the neoplastic cells. Reaction for the proof of alpha mannosidase was positive both in the tumour cells and in the histiocytic elements. Reaction with the NKI-C3 antibody was found to be positive in many tumour cells, the anti S-100 protein antibody less positive. Most of the cells reacted strongly positively with anticytokeratin antibody CAM 5.2. Findings of anticytokeratin antibody positive melanomas have not been published yet. Electron microscopy showed rare melanosomes in some of the neoplastic cells, making it possible to include the tumour in melanomas.

Histocytochemistry↗
PubMed1990

Balloon cell melanoma of the skin. Part II: An electron-microscopic study.

Electron microscopy of an oligomelanotic balloon cell melanoma confirmed the considerable presence of lipid vacuoles in the cytoplasm of the tumours cells. There was also a marked finding of glycogen. The tumour consisted of little cohesive cells only with sporadic specialized intercellular junctions of the desmosome or hemidesmosome type. No tonofibrils could be seen. The cell cytoplasm contained a large amount of cell organelles, while stage II melanosomes were observed only exceptionally. Some of the melanosomes of stage III were difficult to distinguish from the regressively altered cell organelles, particularly from mitochondria and lysosomeś. The prevailing findings of stage II melanosomes rather indicated organelles sui generis than phagocyted organelles. There were infrequent neurosecretory granules in some places of the cytoplasm. Quite numerous Langerhans' cells with Bierbeck's granules were demonstrated among the tumour cells.

Humans↗
PubMed1989

Angioimmunoblastic lymphadenopathy--an update.

Angioimmunoblastic lymphadenopathy (AILD) is a relatively rare serious disorder of the lymphatic system with various organ manifestations and a significant immunological background. It probably represents an abnormal reaction to different chemical and biological antigens. The etiopathogenesis of the disease is still poorly understood. The authors report on findings in a series of five patients with AILD. Stress is laid on polymorphous symptomatology, unpredictable course and on resulting diagnostic as well as therapeutic difficulties in dealing with the disease.

Adult↗
PubMed1989

Mediastinal teratoma and acute megakaryoblastic leukemia.

The association between mediastinal teratoma and acute megakaryoblastic leukemia (AMKL) in a 15-year-old boy is described. The clinical course is compared with 20 previously reported cases of AMKL in children. Chromosome studies at diagnosis of the leukemia showed multiple leukemic stem lines with numerical and structural abnormalities.

Adolescent↗
PubMed1989

[Angioimmunoblastic lymphadenopathy--present problems].

Angioimmunoblastic lymphadenopathy is usually characterized as a lymphoproliferative disease caused by an abnormal reaction to various chemical and biological antigens and the possible development into malignant lymphomas of different types. The authors evaluate clinical and laboratory findings in a group of their patients suffering from the above disease. They emphasize the variable symptomatology, the frequently atypical course and the ensuing diagnostic difficulties.

Adult↗
PubMed1987

Clinicopathological aspects of Richter's syndrome.

Richter's syndrome represents an acute transformation of chronic lymphocytic leukaemia or other type of low-grade malignant non-Hodgkin lymphoma to highly malignant anaplastic large-cell lymphoma. The prognosis of this complication is highly unfavourable. The authors report on eight cases of Richter's syndrome observed in a series of 198 patients with the clinical diagnosis of chronic lymphocytic leukaemia and evaluate some clinicopathological and immunological peculiarities of this disease.

Aged↗