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Biomedical subjects

I Kuriyama

Publications and source records attributed to I Kuriyama.

9 recordsLinked to original sources

Susceptibility of cultured juveniles of several marine fish to the sevenband grouper nervous necrosis virus.

Piscine nodaviruses (betanodaviruses) have been tentatively divided into four genotypes (SJNNV, RGNNV, TPNNV and BFNNV) and it is suggested that host specificity is different among these genotypes. In the present study, a betanodavirus [sevenband grouper nervous necrosis virus (SGNNV)] belonging to the redspotted grouper nervous necrosis virus (RGNNV) genotype, to which most betanodaviruses from warm water fish are identified, was evaluated for its pathogenicity to hatchery-reared juveniles of several marine fish species. When challenged with the virus by a bath method (10(5.1) TCID50 mL(-1)), sevenband grouper, Epinephelus septemfasciatus, Japanese flounder, Paralichthys olivaceus, and tiger puffer, Takifugu rubripes, displayed behavioural abnormalities and mortalities with distinct histopathological signs of viral nervous necrosis and heavily immunostained cells were observed in the central nervous tissues and retina. Bath-challenged rock fish, Sebastiscus marmoratus, and a hybrid of sevenband grouper and kelp grouper, E. moara, did not display any behavioural abnormality or mortality during the experimental period, although many fish showed slight signs of viral infection in nerve cells. Kelp grouper and red sea bream, Pagrus major, showed no behavioural abnormality, mortality or immunohistopathological changes after the virus challenge. These results are, in part, consistent with the natural host range of RGNNV, indicating the complexity in the host specificity of betanodaviruses.

Animals↗

[A case report of a patient repeatedly infected with Ancylostoma duodenale, probably from himself through his artificial anus, and resistant against a single dose of pyrantel pamoate].

A 88 year old Japanese male was repeatedly infected with Ancyclostoma duodenale. He underwent an artificial anus operation about 55 years ago. He appeared to be infected with hookworm earlier than in 1977 and developed severe anemia. Though he was treated with pyrantel pamoate and mebendazole several times, reinfections developed in each time. A possible origin for his reinfections was his own feces defecated through his artificial anus. Unsanitary handling of the anus and the feces exposed himself to oral or percutaneous infection. Besides, a single dose of pyrantel pamoate, usually very effective against Ancylostoma duodenale, was not so effective in this patient. Therefore, we prescribed multiple doses of pyrantel pamoate, and followed by a single dose of mebendazole. However, reinfections still persisted because of his unsanitary behavior.

Aged↗

[Monthly changes in serum alpha 2-globulin and immunoglobulin levels in chronic hemodialysis patients--with special reference to the occurrence of cancer and blood transfusion].

Thirty-eight patients with chronic renal failure who were treated by hemodialysis more than 100 times each, including 13 cancer patients, were examined for serum alpha 2-globulin and immunoglobulin values monthly, the relationship between the possibility of cancer occurrence and the frequency of blood transfusion during hemodialysis was discussed. The alpha 2-globulin value of the patients treated with blood transfusion more than 20 times was significantly higher than that of the patients not receiving blood transfusion. Moreover, the IgA value was reduced and the IgM value was increased. The IgA values of cancer patients found before or during hemodialysis were significantly higher than those of patients without cancer. There was no significant difference between the group who had undergone hemodialysis more than 500 times those who had received it less than 500 times.

Adult↗

Cardiovascular amyloidosis with giant cell reaction.--Two autopsy cases.

Two autopsy cases, a 77-year-old man and a 66-year-old woman, of cardiovascular amyloidosis with many giant cells were reported. These cells were always found adjacent to amyloid masses which were deposited mainly in small arteries and arterioles, and some of them contained amyloid substance in their cytoplasms. The incidence of these cells was high in the heart and in the kidneys of both cases, and in the latter case the cells were found in the majority of the organs varying in degree. The significance of the giant cells, which probably originated from macrophages, were discussed and that giant cells might appear as a foreign body reaction to amyloid substance was presumed.

Aged↗