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Biomedical subjects

I Kurtev

Publications and source records attributed to I Kurtev.

9 recordsLinked to original sources
PubMed1990

[Changes in the ACTH and cortisol values of patients with acute myocardial infarct].

The plasma cortisol and adrenocorticotrophic hormone (ACTH) levels were studied in 12 patients with clinical, laboratory and ECG data for acute myocardial infarction. The changes were followed up during the 1, 3, 8 and 14 day after the onset of the chest pain attack. Increased ACTH and cortisol levels were established in these patients up to the 5 day. The regulatory principle of action of the opposite relation between these two hormones as well as their 24 hour rhythm were disturbed. These stress-induced hormonal changes should be kept in mind in determining the therapeutic conduct in the patients with acute myocardial infarction.

Adrenocorticotropic Hormone↗
PubMed1988

[The thrombocytic beta-thromboglobulin level of patients with blastic leukemia and chronic myeloleukemia].

The thrombocytic beta-thromboglobulin (beta-TG) level--a specific globulin secreted by the alpha-granules--is an important criterion in the contemporary diagnosis of acquired thrombocytopathies. The beta-TG was determined by the radioimmunologic test of the firm "Amersham" in thrombocytic lysates and thrombocyte-poor plasma of 54 persons: 24 patients with acute leukemia, 14 patients with chronic myeloid leukemia and 15 healthy controls. The leukemic patients were with a preliminary proved thrombocytopathy type "empty thrombocytic pool disease" which had been proved via aggregation measurement by the ATP and ADP levels in the thrombocytes and by the thrombocytic factor 4 level. While the intraplatelet beta-TG concentration in acute leukemia and chronic myeloid leukemia was found unchanged, in the patients with acute leukemia its secretion in the plasma was decreased (154.71 + 16.77 ng/10(5) platelets). The data interpretation shows that in these malignant hemopathies the alpha-granules do not take part in the "empty pool disease". In acute leukemia the pathogenesis of the thrombocytopathy is determined by the so-called "thrombocytic secretion paresis" which is confirmed by the thrombocytic factor 4 low level.

Blood Platelets↗
PubMed1981

[Hormonal secretion dynamics in nonalcoholic drug dependence].

The hypophyseal-gonad axis was studied in patients with non-alcoholic narcomania by specific radioimmunologic methods. The subjects examined were males, at an average age of 22.5 and a duration of the disease--3.5 years. Stimulation was conducted to all the subjects examined via synthetic LH--RH in a dose of 50 mkg, the results compared with the response reaction of 20 healthy males at the same age. A statistically significant decrease of testosterone serum concentration was found as well as a preserved response reaction with stimulation. FSH level was also decreased with a statistical significance, with an altered response reaction after stimulation. LH concentration was increased with preserved type response reaction and maximum degree of increase. The results obtained indicate preserved hypophyseal reserves but decreased hypothalamus stimulation, hence reduced sexual functions in the subjects, misappropriating with narcotics.

Adolescent↗