Biomedical subjects

I L Browarsky

Publications and source records attributed to I L Browarsky.

3 recordsLinked to original sources

PubMed1983

Systemic mast cell disease.

We present a case of systemic mast cell disease because of its unusual lack of significant manifestations in skin or bone. Clinicians and pathologists alike must be aware of this entity and consider it when atypical round cell infiltrates are present in visceral organs. It should be included in a differential diagnosis with Hodgkin's and non-Hodgkin's lymphomas, leukemias, myeloproliferative disorders, and a variety of nonneoplastic diseases. Cytochemical stains and electron microscopy may be diagnostic.

Aged↗

PubMed1978

Histiocytic medullary reticulosis: association with myeloproliferative state and desmoplasia.

A patient with histiocytic medullary reticulosis also had two unusual associations: myeloproliferative state and desmoplastic reaction. These alterations appear to be more than mere chance associations, ie, they seem to be intimately involved with the histiocytic proliferation.

Aged↗

PubMed1975

Water-insoluble paraproteins with anticoagulant properties.

A 78-year-old woman, who had received steroid therapy for four years, had strikingly prolonged prothrombin time (PT) and partial thromboplastin time (PTT). The presumptive diagnosis was chronic hemolytic anemia. Platelet count and functions, fibrinogen, and factor XIII assays were all normal, but other factors assayed abnormally low; Sia water-dilution test was positive. When water-insoluble protein was removed by centrifugation, coagulation factors became normal. Dissolution of this precipitate in normal plasma caused marked prolongation of PT and PTT and lower factor assays. Serum electrophoresis showed a homogeneous M spike and an anomalous IgM, lambda-antigenic type in the gamma-globulin zone at point of origin. Ultracentrifugation of serum and of the precipitate showed 10% S17 and almost 100% S17 components, respectively. Five other patients with water-insoluble paraproteins were tested; two were clot-inhibitory.

Aged↗