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I L Gol'dman

Publications and source records attributed to I L Gol'dman.

At least 19 recordsLinked to original sources
PubMed2002

[Transgenic goats in the world's pharmaceutical industry in the XXI century].

In many developed countries, isolation of human pharmaceutical proteins from milk of genetically modified animals is currently a priority. One of the first commercial pharmaceuticals obtained from the milk of transgenic goats, an anticoagulant antithrombin III, developed by Genzyme Transgenic Corporation, an American biotechnological company, will appear on the pharmaceutical market in the nearest future. In this review, we discuss the role of fundamental science in the development of this field of the pharmaceutical industry.

Animals↗
PubMed2000

[New approaches to construction of transgenic animals with high level tissue-specific expression of foreign genes: construction and reconstruction of genomic domains].

The major problems in constructing transgenic animals and approaches to their solution are discussed. Modern views of the structural-functional organization of the eukaryotic genome are considered. The domain hypothesis of the genome organization is analyzed in detail, as many problems associated with a low level and a lack of tissue specificity of transgene expression can be solved at the step of construction (or reconstruction of existing domains).

Animals↗
PubMed1977

[Spatial arrangement of chromosomes in somatic cell nuclei. IV. Homologous chromosomes in guinea pigs and domestic pigs].

Space location of chromosomes in metaphasic cells was investigated using brains of 30 Cavia cobaya and 30 Sus scrofa, in norm and under X-ray treatment (500 r) and dipin action. Conjugation of homologous chromosomes under normal conditions was determined, with a high rate reliability, to be equal to the 0.99 level of measuring, within the limits of the elaborated mathematical model. High rate of translocations of homologous chromosomes were discovered in animals subjected to the above mutagen treatments. The architecture of cell nuclei is discussed.

Animals↗