Serine derivative with antitumor activity.
The sodium salt of N-dichloroacetyl-DL-serine depresses the growth of sarcoma-37 in mice, causing complete regressions of the tumor. The compound is nontoxic to mice in doses up to 4 gm/kg of body weight. The animals do not lose body weight and show no alteration in the formed elements of the blood or in hemoglobin content.