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Biomedical subjects

I Leban

Publications and source records attributed to I Leban.

6 recordsLinked to original sources
PubMed2001

Two dimeric CuII benzoate derivatives solvated with acetonitrile.

The title compounds, tetrakis(micro-benzoato-O:O')bis(2,6-diaminopyridine)-1kappaN,2kappaN-dicopper(II)-acetonitrile (1/2), [Cu(2)(C(7)H(5)O(2))(4)(C(5)H(7)N(3))(2)].2C(2)H(3)N, (I), and bis(acetonitrile)-1kappaN,2kappaN-tetrakis(micro-benzoato-O:O')dicopper(II)-acetonitrile (1/1.5), [Cu(2)(C(7)H(5)O(2))(4)(C(2)H(3)N)(2)].1.5C(2)H(3)N, (II), crystallize as acetonitrile solvates exhibiting different stability. They have similar molecular structures with discrete dimeric units located at crystallographic inversion centres. The copper ions are bridged by four benzoate groups and neutral N-donor ligands, viz. 2,6-diaminopyridine in (I) and acetonitrile in (II), are coordinated at apical positions. The diverse stability is probably due to hydrogen-bond interactions of the solvated acetonitrile molecules with neighbouring dimers in compound (I).

Journal Article↗
PubMed2000

Methyl 1-

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Journal Article↗
PubMed2000

From alpha-carbamoyl-alpha-cyanooxiranes to 3-halogenopyruvamides.

The crystal structures of the first stable alpha-diol from the alpha-halogenopyruvamide series, 3-chloro-2, 2-dihydroxy-3-phenylpropanamide, C(9)H(10)ClNO(3), and three products [3-(4-chlorophenyl)-2-cyano-2,3-epoxypropanamide, C(10)H(7)ClN(2)O(2), 3-bromo-2-cyano-2-hydroxy-3-p-tolylpropanamide, C(11)H(11)BrN(2)O(2), 3-bromo-2-oxo-3-p-tolylpropanamide, C(10)H(10)BrNO(2)] obtained during the systematic synthesis of alpha-halogenopyruvamides are reported. The crystal structures are dominated by hydrogen bonds involving an amide group. The stability of the geminal diol could be ascribed to hydrogen bonds which involve both hydroxyl groups.

Crystallography, X-Ray↗
PubMed1997

Synthesis, crystal structure, and characterization of two metal-quinolone compounds.

Two novel metal-quinolone compounds have been synthesized and characterized by analytical, spectroscopic, and X-ray diffraction methods. The crystal structure of both, (erxH2) [FeCl4]Cl and (kinoH2)[CuCl4]. H2O, is presented and discussed (erxH2 = doubly protonated form of enrofloxacin, kinoH2 = doubly protonated form of the second quinolone). In both compounds, the hydrogen atom is bonded between the 4-keto oxygen O(1) and carboxylic oxygen O(11), thus preventing the bonding of the metal to this part of the molecule. Antimicrobial activities of metal-quinolone compounds were tested against different microorganisms.

Anti-Bacterial Agents↗
PubMed1997

Crystal structure and characterization of the bismuth(III) compound with quinolone family member (ciprofloxacin). Antibacterial study.

Two bismuth(III) compounds of ciprofloxacin (cf) were synthesized. The crystal structure of one--(cfH2) (cfH) [BiCl6].2H2O (cfH2 = doubly protonated molecule of cf, cfH = protonated molecule of cf)--is presented and discussed. The compound crystallizes in the monoclinic space group P 21/c with a = 17.758(4), b = 7.600(10), c = 31.908(6) A, beta = 101.03(2)0, Z = 4. The charge of the isolated hexachlorobismuthate(III) anions is compensated with protonated of molecules (ionic interactions). One of the cf molecules is protonated at carbonyl oxygen O(1) and nitrogen N(24) of the piperazine residue, and the other at N(24) only. Two water molecules participate in the hydrogen bond network. Antimicrobial activity of this compound was tested against different microorganisms. The results of TG and FT-IR measurements are also included.

Anti-Infective Agents↗