The purpose of this study was to evaluate interindividual variation in acute reactions to ethanol. Six young, healthy female subjects participated in a double-blind experiment consisting of two identical alcohol sessions and one control session where glucose was infused instead of ethanol. Alcohol was infused in a standardized way to reach blood alcohol concentration of 1 mg/ml in 1 hr. During the 4 hr-sessions EEG-spectra, smooth pursuit eye movements, various mood variables, BAC and breath alcohol concentrations were studied repeatedly. The results showed that the subjects had a rather repeatable, individual reaction profile as expressed by changes in alpha mean frequency, theta band power, amount of corrective eye movements and subjective intoxication. The sensitivity of the subject to ethanol should thus be expressed as a reaction profile rather than as a change in a single variable.

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