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Biomedical subjects

I Lesný

Publications and source records attributed to I Lesný.

At least 19 recordsLinked to original sources

Disorders of memory of motor sequences in cerebral palsied children.

In 74 children (32 boys, 42 girls) between 7 and 14 years of age with different forms of cerebral palsy (mainly spastic ones) the motor memory was tested with a sequence of movements which had to be remembered at once, after 24 hours and after 5 days. The normal levels were determined by testing 21 healthy children matched as to age as control as (10 boys, 11 girls). Each exercise was evaluated separately as follows: the movement is performed correctly in the right sequence, 2 points; the movement is performed in a wrong sequence, but in the correct group of three exercises, 1 point; the sequence of movements is entirely wrong or the child does not perform the movements at all, 0 points. Thus for each testing a child can get a maximum of 12 points and for all three testings a maximal 36 points. In 48.5% of the CP children a disorder of memory was found, more frequently in left-sided hemiparesis than in right-sided, and more frequently in paucospastic diparesis (without adductor or flexor spasms and without flexor spastic signs in the toes) than in the classical form. Thus a motor memory disorder is part of the natural history of CP.

Adolescent

[Determination of inhibition habituation in the alpha rhythm (eyes open)].

Luria used the term habituation for the phenomenon that the so-called orientation reflex to a certain stimulus is lost when the stimulus is repeated. In the present investigation habituation was tested by opening the eyes during conventional EEG. During the examination the patient was asked twelve times to open and close the eyes. Thus 730 patients aged 4 to 65 years were examined. Habituation developed in 542 patients and was absent in 188. Most frequently it developed between the 7th and 10th opening of the eyes, most frequently after the ninth. It seems thus that habituation of the alpha rhythm after this repetition is a normal bioelektrcical phenomenon and earlier, later or absent habituation is a deviation from the bioelectric norm.

Adolescent

[Central infantile hypotonia syndrome].

Czechoslovak child neurologists devoted much attention to central infantile hypotonic syndrome (CIHS) in a series of investigations conducted in 1959-1986. They found that it is a developmental syndrome caused by affection of the immature brain, and later, at the age of 3-5 years, it disappears or transforms into other syndromes: most frequently cerebellar syndromes and developmental disintegrations (disintegration of the development of the CNS and medium-grade mental retardation). These groups overlap only little. From the hypotonic syndrome also the spastic syndrome or minor cerebral syndromes may develop. CIHS has, similarly as some other manifestations of CNS affections, multiple causes. One of them is most probably a defect of or lack of development of facilitating pathways of gamma fibres from the cerebellum or possibly from the reticular formation of the brain stem to the spinal cord; another probable cause is longer immaturity of the afferent system (which leads finally to developmental disintegration). It may be assumed that the facilitating systems of pathways develop later and are thus more immature and therefore more vulnerable. According to the latest information it seems that in CIHS also the muscular component participates as prenatal cerebral affections can cause myopathy with hypotonia.

Cerebral Palsy

Development of flexor spastic signs in preterm infants.

Fifty-five preterm infants with birthweights between 800 and 2000g and gestational ages between 25 and 33 weeks were repeatedly examined for the Rossolimo and Mendel-Bechterew lower-limb reflexes. Up to 34 weeks conceptional age (CA) an abduction-extension pattern was characteristic. Between 34 and 36 weeks CA the response changed to one implying flexor spasticity, which in some cases lasted throughout the first postnatal trimester. It is thought that this response occurring around 34 to 38 weeks CA is a sign of normal developmental maturation. On the other hand, an extension-abduction response after 38 weeks CA and a flexor response after the first trimester is indicative of delayed motor development and might suggest an upper motor neuron lesion.

Birth Weight