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Biomedical subjects

I Liavåg

Publications and source records attributed to I Liavåg.

At least 19 recordsLinked to original sources
PubMed1988

Detection and treatment of local recurrence.

The chance of a curative reoperation is better in patients with an asymptomatic recurrence than in those with a symptomatic one. Pelvic recurrences are often detected by thorough physical examination. In general, however, the sensitivity of the clinical examination is low, so that about 75% of the patients have symptomatic recurrence when it is detected clinically. Serial examinations of CEA, however, seem at present time to be the best indication of recurrence. Thus, elevated serum CEA concentration seems to predict cancer recurrence correctly in 80-90%.

Carcinoembryonic Antigen↗
PubMed1988

The surgical treatment of gastric cancer: a retrospective study with special reference to total gastrectomy.

A retrospective study of 312 consecutive cases of gastric malignancy treated from 1974 to 1984 is presented. Eighteen patients (6%) had gastrointestinal lymphoma of the stomach. Among the remaining 294 cases with gastric carcinoma, 46 (16%) had carcinoma of the gastric stump after previous resection for peptic ulcer. Fifty-seven percent (167/294) had no distant metastases (MO). Early gastric carcinoma (pT1) occurred in 16 patients (5.8%), among whom four had distant metastases (pT1M1) and another two patients had regional lymph node metastases (pT1N1). Thirty-three percent of the patients had either no surgical treatment or an explorative laparotomy only, and 9% had a palliative bypass operation performed. A curative (48%) or palliative (10%) resection of the stomach was possible in 171/294 patients. Thus, the resectability rate was 58%. Total gastrectomy was performed in 108 cases with either curative (100) or palliative (eight) intention. The 30-day mortality was two and one patients, respectively (2.8%). Crude survival in the whole series was 16% and 11% at 5 and 10 years. After non-randomized curative total gastrectomy (100 cases) or gastric resection (40 cases) crude survival was 40% and 22% at 5 years, and 24% and 16% at 10 years, respectively (P greater than 0.05, n.s.). We found that total gastrectomy with extensive dissection and end-to-end esophago-jejunostomy by the EEA stapler can be performed with a low mortality rate (2% after curative operation) even in the upper age groups.

Adenocarcinoma↗
PubMed1985

Stereological analysis of human parietal cells before and 6 months after vagotomy.

Gastric biopsies from 10 patients were studied before proximal gastric vagotomy (PGV) and 6 months after the operation. The parietal cells were studied light microscopically and electron microscopically, using point-counting stereology. The volume fraction of the mucosa made up of parietal cells was significantly reduced (p less than 0.01) from 13.9% before PGV to 10.6% 6 months after PGV (median values). This reduction corresponded with a decrease of the median cell volume from 4698 microns3 before PGV to 3737 microns3 after the operation (p = 0.01). The ultrastructural composition of the parietal cells was virtually unchanged after the vagotomy, with the exception of a slight but significant reduction of the cell fraction occupied by mitochondria. The fractions of the parietal cell volume occupied by microvilli and tubulovesicular structures were significantly altered during stimulation with pentagastrin. These relative alterations were of the same magnitude before and after PGV.

Adult↗
PubMed1984

Morphometric studies of human parietal cells before and 7 days after proximal gastric vagotomy.

In nine patients, acid titration tests and gastric biopsy specimens were studied before proximal gastric vagotomy (PGV) and 1 week after the operation. When postoperative biopsy specimens were compared with the preoperative ones, no change was found in the thickness of the mucosa. The volume fraction of the mucosa made up of parietal cells was significantly reduced (p less than 0.01) from 13.8% before PGV to 11.2% after PGV (median values). Both before and after the operation, stimulation with pentagastrin was followed by a significant increase in the relative volume of microvilli in parietal cells and a significant reduction of the relative volume of tubulovesicular structures. The magnitude of this ultrastructural response to pentagastrin was similar before and after PGV. The relative volume of lysosome-like structures was significantly increased in parietal cells postoperatively. With this exception, no significant alteration was found when comparing the ultrastructure before and 7 days after PGV.

Adult↗
PubMed1983

Severe toxic reaction to tinidazole.

A physician aged 44 years participated as a volunteer in pharmacokinetic studies with tinidazole (FASIGYN, Pfizer). He received 1600 mg of the drug as an intravenous infusion over 80 min. Shortly afterwards, he fainted and was unconscious for about 10 s. The attack was followed by low blood pressure, nausea and tiredness for several h. The serum concentration of tinidazole was 35.4 mg/l when the attack started. Blood tests showed a normal immunoglobulin E level, and a transient fall in the concentration of complement factor C3 after the infusion. It is concluded that tinidazole caused an acute toxic reaction with subsequent activation of complement factors.

Adult↗