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Biomedical subjects

I Lipshitz

Publications and source records attributed to I Lipshitz.

At least 19 recordsLinked to original sources
PubMed2001

Laser in situ keratomileusis to correct hyperopic shift after radial keratotomy.

PURPOSE: To assess the safety and efficacy of excimer laser in situ keratomileusis (LASIK) to correct hyperopic shift following radial keratotomy (RK). SETTING: Ophthalmic Health Center, Tel Aviv, Israel. METHODS: The study comprised 15 eyes of 12 patients who had uneventful RK and subsequently developed a hyperopic shift. Laser in situ keratomileusis was performed using the Chiron Automated Corneal Shaper and the Nidek EC-5000 excimer laser with 5.5 mm central and 7.5 mm peripheral ablation zones. The corneal flap was 160 microm in thickness and 8.5 mm in diameter. The refractive correction corresponded to the patients' refractive errors. RESULTS: The mean time after RK was 10.46 years +/- 2.21 (SD) and the mean follow-up after LASIK, 7.3 months (range 1 to 42 months). The mean spherical equivalent refraction was corrected from +3.08 +/- 1.02 diopters (D) to -0.16 +/- 0.73 D after LASIK. At the last examination, 12 eyes (80%) had a refractive error within +/-1.00 D of emmetropia and an uncorrected visual acuity of 20/40 or better. No wound dehiscence, epithelial ingrowth, or other significant complication developed in any eye. CONCLUSIONS: Early postoperative results of the correction by LASIK of a hyperopic shift after RK are encouraging, but long-term studies of a larger population group are required to evaluate the method's clinical value.

Adult↗
PubMed1997

Late onset corneal haze after photorefractive keratectomy for moderate and high myopia.

BACKGROUND: Corneal haze after photorefractive keratectomy (PRK) usually appears within 4 weeks after the procedure. A new type of corneal haze, starting relatively late after PRK, is reported. METHODS: The authors reviewed the files of their first 1000 consecutive patients who completed a follow-up of 12 months or more and identified all those who had clear corneas for at least 4 months, after which corneal haze appeared. The clinical course in these patients was evaluated. RESULTS: Late onset corneal haze (LOCH) had occurred in 18 eyes of 17 patients (incidence, 1.8%), appearing 4 to 12 months after PRK and resulting in decreased visual acuity and regression. Treatment with topical steroids or reoperation resulted in partial reversibility of haze and regression. CONCLUSIONS: A new entity of LOCH is described. The appearance of LOCH suggests that corneal healing and remodeling continue for at least 1 year after PRK.

Administration, Topical↗
PubMed1997

Macular hemorrhage after excimer laser photorefractive keratectomy.

We describe three patients with high myopia, 13.0 to 20.0 diopters (D), who had typical myopic macular hemorrhages 1 to 6 months after photorefractive keratectomy (PRK). The hemorrhages eventually resolved, with resultant permanent decrease in vision and pigmentary and atrophic changes in the macula. Highly myopic eyes are predisposed to bleeding in areas of lacquer cracks and to myopic choroidal neovascularization formation. Awareness of potential retinal pathology in patients having PRK and follow-up retinal examinations are warranted.

Adult↗
PubMed1997

Complications of excimer laser photorefractive keratectomy for myopia.

PURPOSE: To evaluate the safety and complication rates of excimer laser photorefractive keratectomy (PRK). SETTING: Assutah Laser Center, Tel-Aviv, Israel. METHODS: This retrospective study evaluated the complication rate after PRK in 825 consecutive patients who had PRK for myopia and had a follow-up of at least 12 months. RESULTS: At 12 months postoperatively, 4.0% of patients suffered from overcorrection and 8.6% from undercorrection. Induced astigmatism developed in 1.4% of all operated eyes. Three percent of the patients had haze, and 3.6% reported glare or halos. Twenty-three eyes (2.7%) lost one line or more of best corrected visual acuity (BCVA). Ptosis developed in 0.4% of the eyes, and 3.5% had a significant increase in intraocular pressure resulting from corticosteroid treatment. There were no complications in 678 eyes (82.5%). CONCLUSION: Eighty-two percent of eyes having PRK did not develop complications. In 18.0% one or more complication, mainly undercorrection, overcorrection, or loss of BCVA, occurred.

Administration, Topical↗
PubMed1997

Excimer laser reablation.

BACKGROUND AND OBJECTIVE: To evaluate the outcome of repeated excimer laser keratectomy after photorefractive keratectomy (PRK). PATIENTS AND METHODS: A retrospective study of 32 of 1000 consecutive patients who had a follow-up of at least 12 months and who underwent repeated PRK in the Assutah Laser Center. RESULTS: The mean spherical equivalent (SE) declined significantly as a result of the repeated treatment. As opposed to zero eyes before re-treatment, 19 of 29 eyes (66%) achieved SE of within +/-1 D 6 months after re-treatment. Before re-treatment, 20 of 32 eyes (62%) had medium or severe haze, whereas after re-treatment only 1 of 29 eyes (3%) had medium haze, and none of the eyes had severe haze. At 6 months after reoperation, visual acuity had improved to 20/36, a significant improvement to the mean log MAR equivalent of 20/40 before re-treatment, yet still significantly worse than the log MAR equivalent before initial ablation which was 20/30. CONCLUSION: Repeated excimer laser PRK has the potential for successful treatment of undercorrection, regression, and haze occurring after an initial PRK.

Corneal Opacity↗
PubMed1997

An intraocular telescopic lens for macular degeneration.

Age-related macular degeneration is a leading cause of visual loss in adults older than 60 years of age. Once vision has been seriously compromised, the only means of improving visual function are optical devices that produce magnification of images. These devices fall into three categories: (1) high-plus lenses, (2) external telescopes, and (3) a high-minus center intraocular lens combined with external high-plus glasses. The authors designed a new intraocular lens with an entire telescope in its center. In vitro tests were performed to evaluate modulation transfer function, visual field, and optical aberrations. Implantation in cadaver eyes was performed to test the surgical technique and safety. Test results showed that satisfactory modulation transfer function and optic aberration were achieved, and implantation in cadaver eyes was proven to be feasible and safe. It was concluded that a fully implanted intraocular telescopic lens is an effective optical solution for age-related macular degeneration.

Adult↗
PubMed1993

[Excimer laser correction of myopia].

Excimer laser photorefractive keratectomy was performed on 100 myopic eyes. The preoperative spherical equivalent of myopia ranged from -2.00 to -9.99 diopters (D), mean -4.80 +/- 2.20 D. The procedure was performed under local anesthesia using 0.4% topical benoxinate HCl; corticosteroid eye drops were then used for up to 3 months. All patients achieved corrected visual acuity within 1 line of corrected preoperative visual acuity. The only complication was subepithelial reticular haze seen in all patients, which peaked at 4 weeks after the procedure and gradually diminished within 3 months. After follow-up of from 6-11 months, 93% of patients had achieved uncorrected visual acuity of 6/12 or better. Mean postoperative refraction was -0.20 +/- 0.97 D. 69% achieved a correction within +/- 0.50 diopter of emmetropia, 85% within +/- 1.00 D and 96% achieved corrected visual acuity of within 1 line of preoperative corrected visual acuity. This study and those in the literature show excimer laser to be a promising surgical treatment for myopia.

Follow-Up Studies↗
PubMed1985

Beta-adrenergic-stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes.

Beta-adrenergic-associated cyclic AMP accumulation was studied in intact lymphocytes before and after transformation with Epstein-Barr virus into immortal cell lines. Although a marked reduction in isoproterenol-stimulated cyclic AMP synthesis was observed in transformed cells, forskolin-stimulated cyclic AMP accumulation was preserved. A parallel loss of 125-iodocyanopindolol binding sites suggests that the reduction in beta-adrenergic-stimulated AMP synthesis is due to receptor down-regulation.

Adenylyl Cyclases↗
PubMed1979

Erythema nodosum associated with pregnancy. Case reports.

Four cases of erythema nodosum associated with pregnancy are reported and the literature reviewed. Erythema nodosum in pregnancy is a self-limited condition requiring minimal supportive treatment. No adverse effects upon pregnancy course or fetal outcome were noted. It is suggested that pregnancy may serve as an etiological basis for the disease.

Adult↗
PubMedDate not supplied

The effect of spherical photorefractive keratectomy on myopic astigmatism.

The aim of this report is to present the effects of spherical photorefractive keratectomy (PRK) by excimer laser on myopic astigmatism. Spherical PRK was performed in 96 eyes with myopia associated with astigmatism of between 0.75 and 2.00 diopters (D) using the Summit excimer laser. The reduction both in sphere and in cylinder was found to be highly statistically significant (P < 0.0001 for both). The mean reduction of cylinder was 46%. Astigmatic error of less than 2.00 D can be corrected significantly by spherical PRK.

Adult↗
PubMedDate not supplied

Symmetry of outcome after photorefractive keratectomy for myopia.

The aim of this study was to find out whether the outcome of excimer laser photorefractive keratectomy (PRK) in the second eye can be predicted from the results of the first, and to determine whether we should modify our therapeutic approach to the second eye according to the results of the first. Bilateral PRK was performed in 73 patients using the Summit Technology excimer laser. All patients included in this study had a follow-up of at least 12 months in both eyes. The change of refraction and the haze of the two eyes were compared. Sixty percent of patients had a difference in refraction between the two eyes smaller than 0.50 diopters (D), and 75% had a difference smaller than 1.00 D. The degree of symmetry in response to treatment was greater in patients with a preoperative spherical equivalent refraction of less than -6.00 D. Most patients had a similar degree of haze in both eyes. The results of our study demonstrate that a considerable degree of symmetry in the outcome of surgery exists between the two eyes of the same patient undergoing PRK, especially in low to moderate myopia.

Adolescent↗