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Biomedical subjects

I Lo

Publications and source records attributed to I Lo.

At least 19 recordsLinked to original sources
PubMed2003

[Fractionation of the total extract of Khaya senegalensis Barks. Value of the formulation of an anti-inflammatory ointment].

The aim of this work was to compare the anti-inflammatory activity of the total extract of Khaya senegalensis Barks and its different fractions for optimizing the active ingredients which be used in the ointment formulation. For that, a fractionation was performed followed by anti-inflammatory tests based on the method of the croton oil induced oedema. Three fractions were obtained and the comparison of their activity with the one of the total extract has shown the following results: 37.10%, 45.65%, 22.30% and 22.36% respectively for the extract, fraction n1, fraction n2 and fraction n3. The statistical analysis ofthe results (Student Test; p = 0.05) have revealed that the fraction nl is significatively more active than the others. However, there was not a significant difference between the inhibition induced by the fraction n1 and the total extact one, even the mean value of this latter is lower. Therefore, it seems enough to use the total extract as active ingredient for developing an anti-inflammatory ointment.

Animals↗
PubMed2002

[Preparation of a syrup with Bakis roots (Tinospora bakis) and evaluation of its choleretic activity in rats].

The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity. Indeed, when it was used at a dose of about 7.5 mg/100 g of weight, the sirup induced a significant increase of bilary secretion in healthy rats and cholestatic rats, confirming the results observed with the aqueous extract. Therefore, futher investigations in order to improve the quality of the sirup can be considered before performing clinical trials.

Animals↗
PubMed2000

[Inflammatory ointment from shea butter and hydro-alcoholic extract of Khaya senegalensis barks (Cailcederat)].

In a former study, it was proved that the alcoholic solution of hydro-alcoholic extract of Khaya senegalensis barks had an anti-inflammatory activity on animals after a local application. In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by the method of the croton oil inhibited ear oedema. Results showed inhibition percentages of the ear oedema of 58.8%, 66.7% and 75.4% when the hydro-alcoholic extract was tested at respective doses of 1%, 2% and 3% in shea butter. The two other excipients, (vaceline and Lanoline) tested at the dose of 3% showed between 52% and 58% of inhibitions. The interest of this study was to demonstrate the possibility to maintain the anti-inflammatory activity of Khaya senegalensis barks by using them in a galenic form, easy to prepare and which is, in addition, more adapted than the extract to possible clinical trials.

Administration, Cutaneous↗
PubMed1999

In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis.

We previously observed that aqueous extracts of the stem bark and leaves of Khaya senegalensis exhibited a strong antisickling activity. These results prompted us to find out the constituent(s) responsible for these properties using an in vitro bio-guided fractionation. The bioassay was based on sickle cells countings, before and after deoxygenation, in blood samples taken from patients with severe sickle cell anemia and pre-incubated with the drugs to be tested. The main active constituent was identified as a rearranged limonoid whose structure was recently elucidated. In comparison with pentoxifylline used as standard, the in vitro antisickling activity of this limonoid was much higher at any concentrations and incubation conditions. In addition, it did not alter significantly the corpuscular indices.

Adolescent↗
PubMed1999

[Anti-inflammatory activity of the bark of Khaya senegalensis (A Juss). Preliminary research of structure/activity relationship].

Some anti-inflammatory tests based on the carrageenan induced oedema rat paw method have been carried out with a freeze-dried aqueous extract and an etheropetrolic extract of Cailcedrat (Khaya senegalensis) barks. Then, a preliminary chemical study to find a relation structure/activity has been done from the etheropetrolic extract, by using various chromatography technicals. The achieved results have shown a decrease of the oedema by 14% when the aqueous extract is used at 1 g.kg-1, 21.5% and 62% with the etheropetrolic extract used at the respecive doses of 0.5 g.kg-1 and 1 g.kg-1. As for the chemical study, it allowed the separation of two compounds which probably take part in noticed activity and are supposed to be methyl angolensate and methyl hydroxyangolensate.

Animals↗
PubMed1995

Combined central slip and volar plate injuries at the PIP joint.

PIP joint injuries are common. We describe an unusual injury in which an apparent volar plate avulsion injury was associated with a dorsal, central slip avulsion fracture. We postulate that the mechanism of injury would appear to have been forced flexion with the central slip being avulsed and the volar plate fracture occurring as a secondary impingement fracture. Our two cases were treated with full extension splinting with satisfactory results.

Adolescent↗
PubMed1990

Human papillomavirus in oesophageal squamous cell carcinoma.

Thirty seven cases of oesophageal squamous cell carcinoma were studied by applying DNA slot blot analysis and in situ hybridisation using type specific probes for HPV 6, 11, 16 and 18. Cases of condyloma accuminata, cervical carcinoma, and laryngeal papilloma were used as controls. Blocks including areas of invasive carcinoma, intraepithelial neoplasia, and normal epithelium were studied in each case. No HPV genome was detectable in any of the oesophageal cases. It is concluded that these types of HPV do not have an association with oesophageal squamous cell carcinoma.

Carcinoma, Squamous Cell↗