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Biomedical subjects

I M Clarke

Publications and source records attributed to I M Clarke.

At least 19 recordsLinked to original sources
PubMed1994

Personality factors and the practice of anaesthesia: a psychometric evaluation.

The purpose of this study was to examine personality profiles of Canadian anaesthetists and to investigate the role of personality variables in anaesthetist's job satisfaction. Three hundred and thirty senior Canadian anaesthetists completed the Cattell 16PF personality inventory. A brief demographic questionnaire inquired about special interests and job satisfaction. This paper reports the initial analysis of the replies. Most anaesthetists were very satisfied with their work. Female anaesthetists are more tender-minded, sensitive and over-protective than their male colleagues.

Adult↗
PubMed1993

Peppering pain.

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Animals↗
PubMed1981

Amitriptyline and perphenazine (Triptafen DA) in chronic pain.

One-hundred and twenty patients with chronic pain, who had all failed to obtain relief with traditional medical treatment, were given a standard psychotropic drug mixture consisting of amitriptyline 25 mg and perphenazine 2 mg. Of those who completed 2 months of treatment, 33.68% were pain free, while 8.3% had unacceptable side-effects. The best results were obtained in patients with postherpetic neuralgia and postoperative scar pain.

Amitriptyline↗
PubMed1975

Evaluation of creatinine phosphokinase in screening patients for malignant hyperpyrexia.

Evidence is presented that serum creatinine phosphokinase (CPK) activity is of no direct value in screening patients for susceptibility to malignant hyperpyrexia and does not correlate with halothane-induced muscle contracture or the presence of myopathy. Widely differing CPK values were found at different times in the same people. In most "malignant hyperpyrexia" families the susceptible patients had either normal or inconsistently raised CPK values.

Creatine Kinase↗
PubMed1975

An evaluation of procaine in the treatment of malignant hyperpyrexia.

Procaine has been advocated in the treatment of malignant hyperpyrexia, whereas lignocaine has been shown to worsen the condition. Using muscle from patients susceptible to malignant hyperpyrexia in vitro, it has been demonstrated that muscle contracture can occur with procaine on its own, and in one patient the halothane-induced contracture was potentiated by procaine. In other patients the concentration of procaine required to abolish the halothane-induced contracture was markedly above the clinical dose range. In a study of lignociane and procaine on a caffeinated rat muscle (a suggested model for malignant hyperpyrexia) no significant difference was found in the ability of these local anaesthetics to alter resting tension of halothane-treated muscle; with both drugs the resting tension rose in a dose-related manner. The use of procaine as the drug of first choice in patients with malignant hyperpyrexia is challenged.

Anesthesia, General↗