PubMed Health⌕ Search

Biomedical subjects

I M Kolotygina

Publications and source records attributed to I M Kolotygina.

7 recordsLinked to original sources
PubMed1990

[Action of carcinogenesis promoters on the adhesive force of cells in the liver, lung and thyroid gland in rats and mice].

The short-term effects of the carcinogenesis promoters on the adhesive force of cells are compared with the data from literature on their ability to exert a promoter action on the carcinogenesis development in the same organs during prolonged introduction after an initiator. The ability of substances to decrease the adhesive force in the tissue below the resistance threshold is established to correlate with its promoter activity. The coincidence of tissue specificity of both effects and active doses of substances is observed.

Animals↗
PubMedDate not supplied

[Stability threshold of a tissue system].

Studies of changes in the cells adhesive force during spontaneous and induced cancerogenesis, as well as under the effect of cancerogenesis promotors permits to reveal the cells adhesion forces critical values which separate tissue states stable and unstable to blastomogenesis. These data are analysed proceeding from the concepts on generalized cooperative transitions in the membranes and their role in the control over biological systems. It is taken into account that the membranes and cytoskeleton elements are the most important systems of the tissue mechanical integration, and phase transitions proceeding in them must be reflected in the tissue mechanical properties.

Adenoma↗
PubMedDate not supplied

[Cell surface RNA--a possible molecular receptor of adaptogens].

When RNA of the cell surface is destroyed with RNAase, the effect of adaptogenes is removed. Such effect is produced by introduction of actinomycin D 30 minutes before intake of adaptogene. Destruction of surface RNA stimulates protein synthesis. Comparison of these facts permits a hypothesis to be advanced saying that surface RNA is a receptor of adaptogenes obtained from plants of Aralia family.

Adaptation, Physiological↗