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Biomedical subjects

I M Kvetnoĭ

Publications and source records attributed to I M Kvetnoĭ.

At least 19 recordsLinked to original sources
PubMed2006

[Clinicodiagnostic significance of gastroesophageal reflux and structural changes in the esophagus and stomach in bronchial asthma].

Four hundred patients with bronchial asthma (BA) were questioned. Complex clinical and instrumental examination of 60 patients with BA and endoscopic-positive gastroesophageal reflux disease was carried out; the control groups included 30 patients with BA alone and 30 patients with GERD alone. Clinical symptoms of GERD were revealed in 58% of BA patients; endoscopic-positive GERD was diagnosed in 48.6% of BA patients. The study proved the connection between the degree of respiratory disturbances, on the one hand, and the degree of esophagitis and the level of intraesophageal pH, on the other, in patients with BA plus GERD. The study also established the role of esophageal and gastric epitheliocytes, producing endothelin-1, melatonin, NO-synthase, and calretinin, in the occurrence of mutual exacerbation syndrome.

Adult↗
PubMed2004

[Neuroendocrinology of the stomach and aging].

The survey contains information about basic stomach endocrine cells in normal condition and their changes in chronic atrophic gastritis and ageing. The data of modern research devoted to endocrine cells age-related changes are represented here and analyzed. The reasons that influence on endocrine cells age-related changes and the ways of their possible correction are described.

Aging↗
PubMed2003

[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age].

The experiments were performed in mice with transplanted Lewis lung carcinoma. The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice. There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old. Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml. The results obtained suggested that perspective preparates in the cancer therapy--vilon and cytostatic drugs-, must be used not synchronously.

Aging↗
PubMed2002

[Contribution of I. V. Davydovskiy in the development of gerontology].

This article represents a historical review concerning a period of work of prominent Russian pathologist Prof. I. Davydovski on a field of gerontology. At the end of his professional activity I. Davydovski has organized a gerontological laboratory. His research works have been summarized in the popular monograph "Gerontology", which appeared in 1966. This book served as a guidance in general and systemic gerontology for many years.

Aged↗
PubMed2001

[Growth kinetics and functional morphology of M-1 sarcoma in rats before and after gamma-irradiation].

The study was concerned with growth of sarcoma M-1 and basic morphological characteristics of proliferative activity of cells of this strain as well as apoptosis of cells at different stages of tumor progression in rats before and after a single gamma irradiation at 30 Gy. At the parenchymal periphery which determines tumor growth, the PCNA index of proliferating cells was 76.5%; spontaneous cell death--0.28%. During post-irradiation period, the sarcoma PCNA index fell to 62.3% while the apoptotic index rose five-fold. These findings support the concept of radiation-induced apoptosis being a major pathogenetic factor responsible for effectiveness of radiotherapy of tumors. Indirect evidence on PCNA immunostaining suggested that synthesis of this cyclin is sensitive to the level of oxygen input in the cell, yet it offers sufficient resistance to gamma-radiation.

Animals↗
PubMed2001

[Thymus and aging].

This review is devoted to the analysis of current knowledge on the structure-functional organization of thymus, its role in homeostasis regulation and in mechanisms of ageing.

Aging↗
PubMed2001

[Morphofunctional characteristics of endocrine gastric cells in chronic biliary pancreatitis].

Clinicoendoscopic morphological and morphofunctional studies in 50 patients with chronic cholecystitis and 50 patients with chronic biliary pancreatitis have demonstrated that morphometric analysis of the antral stomach endocrine cells secreting melatonin, neurotensin and somatostatin can be used in addition to standard laboratory and device methods for differentiation chronic biliary pancreatitis with biliary pathology.

Chronic Disease↗
PubMed2001

[Effect of epithalone on growth kinetics and functional morphology of M-1 sarcoma].

The growth of subcutaneously-transplanted sarcoma M-1 in rat was inhibited by injection of a synthetic tetrapeptide--epitalon (2.5 (micrograms/kg). The effect lasted for two weeks after injection course. Decrease in proliferative activity was not associated with the drug's immediate cytostatic action on tumor cells. The specific mechanism of the drug's action via blood flow was shown by morphological signs of hemorrhagic necrosis of tumor and increased apoptosis of tumor cells.

Animals↗
PubMed2000

[Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations].

AIM: To study functional morphology of a total population of endocrine cells of colon mucosa, mast and enterochromaffine cells. MATERIALS AND METHODS: Light and electrone microscopy, immunohistochemical methods, morphometry were used to study endocrine and mast cells of the sigmoid colon in inflammation. RESULTS: Changes of functional morphology and size of endocrine and mast cell population as well as apudocytes producing serotonin, melatonin, vasointestinal peptides were stated. Apudocyte and mass cell functional morphology, clinical symptoms and mucosal structural changes correlated. Specificity of some parameters in Chron's disease is shown. CONCLUSION: The results may provide additional criteria in diagnosis of different variants of chronic colitis.

APUD Cells↗
PubMed2000

[Melatonin and serotonin in inflammatory colon diseases and colorectal neoplasms].

Patients with inflammatory intestinal diseases and colorectal adenocarcinoma in sigmoid mucosa were examined using light and electron microscopy, immunohistochemical tests, radioimmunoassay and morphometry. Functional morphology of the general population of the endocrine cells and apudocytes producing melatonin and serotonin as well as urine excretion of 6-sulfatoxymelatonin changed in quality and quantity. The parameters showed specificity depending on clinicomorphological variant of colorectal pathology. The findings provide additional criteria in diagnosis and prediction of the course of different types of inflammatory and tumor affections of the colon.

APUD Cells↗
PubMed1999

[Changes in the APUD system of the large intestine as a risk factor for colorectal cancer].

A common population of endocrine cells, apudocytes producing serotonin, melatonin, vaso-intestinal peptides and mast cells were examined on unaffected mucous membranes of 27 colorectal cancer patients. Light and electron microscopy, immunohistochemical and morphometric methods were used. A marked decrease in total number of apudocytes, hypoplasia of cells producing serotonin, melatonin, vaso-intestinal peptides were revealed at early stages of cancer irrespective of the tumor structure. Mast cells in premetastatic period outnumbered those after emergence of metastases. The results obtained may serve as additional criteria of early colorectal cancer diagnosis.

APUD Cells↗