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Biomedical subjects

I M Rabinowicz

Publications and source records attributed to I M Rabinowicz.

9 recordsLinked to original sources

Anomalous intracranial venous drainage mimicking orbital or cavernous arteriovenous fistula.

A 9-year-old child presented with right eye swelling and bluish discoloration over the periorbital region. MR and CT displayed prominent vessels within the orbit and in the facial region, suggesting a carotid-cavernous fistula. Doppler ultrasound indicated the vascular engorgement was not secondary to a proximal arteriovenous shunt. Arteriography with its inherent time sequence image capability prompted the proper diagnosis of bilateral atresia of the sigmoid sinuses.

Arteriovenous Fistula↗

Ocular findings in infants treated with extracorporeal membrane oxygenator support.

Eleven infants treated with extracorporeal membrane oxygenator support were examined for ocular complications. Four patients were noted to have retinal and external ocular vascular changes on the left but not on the right. These unilateral findings are believed to be related to right common carotid and internal jugular occlusion. The proposed mechanism involves three factors: cerebral venous congestion, impairment of cerebral and possibly retinal arterial autoregulation, and higher cerebral arterial blood flow on the left compared with the right.

Extracorporeal Membrane Oxygenation↗

Subacute zygomycosis of the orbit.

A zygomycotic (phycomycotic) orbital cellulitis developed in a healthy 9-year-old boy. Because of the involved tissue's unfamiliar histopathologic features, an initial diagnosis of eosinophilic granuloma was made and appropriate treatment was delayed for more than six months. The patient's slowly progressive form of zygomycosis was clinically and morphologically similar to that described in previously recorded cases. All three cases occurred in otherwise healthy children living within the United States. Their involved tissues had mixed histopathologic features of chronic granulomatous entomophthoramycosis and acute necrotizing mucormycosis; however, unlike entomophthoramycosis, the fungi in these cases may invade the walls of blood vessels and cause severe tissue necrosis. We believe that these three cases represent a distinct clinicopathologic variant of facial-cranial zygomycosis not previously delineated in the literature. Although they are aggressive, these infections are not as fulminant as in classic mucormycosis, but can nevertheless be lethal.

Child↗

Uveitis complicating autoimmune chronic active hepatitis.

A patient with autoimmune hepatitis B surface antigen-negative chronic active hepatitis (CAH) developed uveitis during the course of her disease. The occurrence of this eye disorder provides additional support for an autoimmune pathogenesis for CAH. Clinicians should be alert to the association of uveitis with CAH, so that patients at risk may be examined for this potentially serious ocular disease.

Autoimmune Diseases↗

Sclerocornea associated with the Smith-Lemli-Opitz syndrome.

A 2,000-g infant boy had many features of the Smith-Lemli-Opitz syndrome (prenatal growth deficiency and developmental retardation, microcephaly with unusual facies, hypospadias, and feeding difficulties) as well as sclerocornea. The association of this rare eye finding with this rare congenital syndrome is unique. Successful penetrating keratoplasty was performed in one eye at 8 months of age.

Abnormalities, Multiple↗

Early surgery and visual correction of an infant born with unilateral eye lens opacity.

A healthy neonate born with unilateral cataract was operated upon on Life Day 4. Visual correction and testing were initiated promptly. Resolution showed continuous improvement in the normal eye, with no improvement noted in the operated eye until adequate visual correction was provided. Following correction there was prompt marked improvement of visual resolution.

Cataract↗

Periocular congenital melanocytic nevi.

Large congenital melanocytic nevi (CMN) are cutaneous malformations of neural crest origin that have a notorious reputation because of their reported propensity to undergo malignant degeneration. Traditionally, complete surgical excision has been advocated based on the premise that large CMN are a precursor to melanoma. Two cases of large periocular CMN are reported to emphasize the importance of distinguishing them from other congenital skin lesions. Data from the literature support the contention that these pigmented skin lesions spawn malignancies and that prophylactic therapy may be indicated.

Child, Preschool↗