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Biomedical subjects

I M Reid

Publications and source records attributed to I M Reid.

At least 37 records · Page 2Linked to original sources
PubMed1978

Effects of anabolic steroids on liver cell ultrastructure in sheep.

Castrated male sheep were sham inplanted or implanted with estradiol, trenbolone acetate or trenbolone acetate in combination with estradiol, and slaughtered after 56 days. Ultrastructural and morphometric examination of the livers of steroid-treated sheep showed an increase in the volume density of the cell occupied by rough endoplasmic reticulum and microbodies. In four of the eight sheep treated with trenbolone acetate, either alone or in combination with estradiol, enlarged mitochondria with crystalline inclusions were seen. The increase in hepatic rough endoplasmic reticulum may be of benefit to the sheep whereas the mitochondrial changes after anabolic steroid use indicate a cellular lesion of unknown significance for health.

Animals↗
PubMed1975

An ultrastructural and biochemical study of hexachlorophane-induced fatty liver in sheep.

The administration of single or multiple oral doses of hexachlorophane to yearling sheep resulted in a periportal fatty liver. The accumulation of fat is accompanied by ultrastructural changes in the hepatocyte organelles, particularly the endoplasmic reticulum and Golgi apparatus, and by decreased serum lipid and triglyceride levels. It is suggested that an impairment in the triglyceride secretory mechanism of the liver cell may be the patho-physiological basis for fatty liver. However, the changes in the liver were not accompanied by an evidence of significant impairment of liver cell function.

Alcohol Oxidoreductases↗