Biomedical subjects
Publications and source records attributed to I M Spence.
It is now accepted that the herpesvirus group is an aetiological agent in oesophagitis, and it is known to play a role in various neoplasias. This is the first report of the finding by electron microscopy of herpesvirus in biopsy material from a clinically diagnosed case of oesophageal carcinoma.
Electron microscopic examination of epidermal tissue adjacent to a skin melanoma in a White male showed the presence of 24 nm particles within a cytoplasmic vacuole. No aetiological significance can be attributed to this single finding but it is possible that examination of tissues proximal to these neoplasms may be of value. As these tumors induce strong antibody responses in allogeneic and xenogeneic hosts it has often been suggested that they may be viral in origin.
Astrovirus was identified in stool samples from a 6-month-old White infant up to 8 days after the onset of gastro-enteritis. Large immune aggregates were found after treatment of the faecal specimen with pooled human immunoglobulin.
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Electron microscopic examination of nerve tissue from a patient with polymyalgia arteritis has shown the presence of electron-dense particles within the axons. These particles have a viral-like structure but lie within the size range of small neurosecretory vesicles and may represent alterations in these organelles. Myelin-like bodies have also been identified within non-myelinated axons and are suggestive of lysosomal end-products. These findings seem to bear out the proposition that the primary lesion in polymyalgia arteritis may be neurogenic in origin and offer some explanation of the pain experienced in the course of the disease.
The properties of a new cell line derived from a human retroperitoneal liposarcoma are described. The cells do not grow at low cell concentrations and contain in their cytoplasm large numbers of droplets that stain with Oil Red O. No indication of the presence of endogenous virus particles could be found. The mean chromosome number per cell is 36, with several constant markers, the most conspicuous of which is a large submetacentric marker due to a translocation between chromosomes 4 and 11, which is present in every cell. The liposarcoma cells show an enhanced uptake of [14C]acetate compared to normal human fibroblasts.
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