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Biomedical subjects

I M Vinnitskiĭ

Publications and source records attributed to I M Vinnitskiĭ.

15 recordsLinked to original sources
PubMedDate not supplied

[Effect of benzodiazepine receptor blockade on memory processes in the mouse].

The results of study testify to a stimulating effect of benzodiazepine receptors blocators RO15-1788 and RO15-3505 on reproduction of conditioned reaction of passive avoidance in mice disturbed as a result of various procedures-"psychogenic" and cycloheximide amnesia, extinction and forgetting. A considerable antiamnesic effect of the drugs on cycloheximide amnesia models is noted, in comparison with the "psychogenic" one. RO15-3505 is more effective in the processes of extraction of memory traces under amnesia. The obtained results testify to an important contribution of benzodiazepine-GABA-ergic brain systems in inhibitory regulation of the processes of stored memory traces reproduction.

Amnesia↗
PubMedDate not supplied

[Bupropion activation of memory trace retrieval in amnesia and forgetting].

The effect of a new antidepressant bupropion on the processes of retrieval of the conditioned response of passive avoidance in mice under amnesia of different genesis and spontaneous forgetting was studied. The drug was shown to exert the antiamnesic effect and to facilitate retrieval of amnesia-affected or forgotten memory trace. The maximal effect of bupropion was observed at the dosage of 30 mg/kg. At the use of bupropion on the 2nd day after exertion of amnesic influences there was registered the tendency to prolongation of preservation of the conditioned habit enhanced retrieval as compared with greater time periods. The drug effect under memory trace retrieval impaired by cycloheximide-induced amnesia was similar in the action but more pronounced than that under "psychogenic" amnesia. The data obtained testify in favour of an active involvement of the brain dopaminergic system in the processes of memory trace retrieval.

Amnesia↗
PubMedDate not supplied

[Antiamnesic action of nomifensine].

Nomifensine efficiency in the improvement of memory trace restoration impaired by spontaneous forgetting or amnesic influence was demonstrated in experiments on BALB/c mice by using the passive avoidance technique. Doses of 10-20 mg/kg proved to be the most efficient. The presented results suggest that the antiamnesic effect of nomifensine is due to the activation of dopaminergic and noradrenergic systems.

Amnesia↗
PubMedDate not supplied

[Reproduction of a memory trace in amnesia and forgetting following alteration in the activity of pre- and postsynaptic dopamine receptors].

The paper deals with analysis of the action of enantiomers 3-PPP on memory trace reproduction disturbed by amnestic effects and spontaneous forgetting in mice. A considerable antiamnestic effect is shown of (+)3-PPP and (-)3-PPP in 10 mg/kg doze changing the activity of postsynaptic dopamine receptors. The influence of drugs in 2 mg/kg doze changing the activity of presynaptic receptors consisted in recovery of conditioned habit only in situation of a weak amnestic effect and at forgetting, when the level of reproduction was like a weak amnesia. The range of enantiomers 3-PPP action on reproduction processes disturbed by amnesia or forgetting is determined by the possibility of specific activation of pre- and postsynaptic receptors at different depth of disturbances of memory trace reproduction causing differentiation of 3-PPP effects.

Amnesia↗
PubMedDate not supplied

[Facilitation of memory trace retrieval by the action of amfonelic acid].

Amfonelic acid exerting the central dopaminergic effect was studied on mice by the passive avoidance conditioned response method under amnesia induced by leaving the animals in a dark chamber following electrocutaneous stimulation and different terms of natural forgetting. Amfonelic acid was shown to prevent the amnesic effect, to improve retrieval of the conditioned response decreased as a result of amnesia or prolonged forgetting.

Amnesia↗
PubMedDate not supplied

[Impairment of the formation of conditioned avoidance reactions following destruction of the ventral amygdalofugal pathway].

Formation of conditioned "passive" avoidance reaction was studied in rats with one-time pain reinforcement after electrolitic destruction of mesencephalitic part of the central gray substance (CGS). The destruction of CGS ventral nuclei at the level of the midbrain rostral part led to a decrease in emotional reaction of "fear" and to disturbance of avoidance formation. The participation of midbrain limbic structures in learning and memory is discussed.

Amygdala↗
PubMedDate not supplied

[Formation of a conditioned "passive" avoidance reaction following ablation of the midbrain central gray].

Formation of conditioned "passive" avoidance reaction was studied in rats with a single pain reinforcement after electrolythic destruction of mesencephalic part of the central gray substance (CGS). The ablation of CGS ventral nuclei at the level of the midbrain rostral part led to a decrease in emotional reaction of "fears" and to disturbance of avoidance conditioning. The participation of midbrain limbic structures in learning and memory is discussed.

Animals↗
PubMedDate not supplied

[Role of the stria terminalis in the formation of passive-defensive behavior in the rat].

The formation of conditioned passive avoidance reaction (CAR) to a single pain reinforcement was studied in rats following electrolytic dissection of the stria terminalis (ST). Total ST dissection did not affect spontaneous motor activity and vegetative manifestations, though it deprived the animals of the ability to choose an adequate motor response when reproducing CAR. Hence, the ST integrity is essential for the formation of the motor component of the conditioned reaction. Separate dissection of the pre- and postcommissural ST components has shown that determining in the CAR formation is the integrity of the postcommissural component which contains fibres afferent for the amygdaloid complex. Dissection of the precommissural component consisting exclusively of efferent fibres did not affect CAR manifestation. The stria terminalis is probably an afferent activating way for the amygdaloid complex which achieves modulation of defensive conditioned behaviour.

Amygdala↗
PubMedDate not supplied

[Effect of destruction of individual nuclei of the amygdaloid complex on elaboration of avoidance reaction in rats].

Formation of one-trial passive avoidance reactions (PAR) after bilateral symmetrical ablations of some nuclei of the amygdala complex (AC) was studied in Wistar male rats. Some nuclei belonging to the corticomedial or basolateral group of AC nuclei were subjected to electrolythical ablation. It has been found that ablations of individual AC nuclei statistically significantly prevent PAR elaboration. The data obtained are interpreted from the standpoint of disturbance of the morpho-functional organization of the AC efferent systems.

Amygdala↗