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Biomedical subjects

I M Weisbrot

Publications and source records attributed to I M Weisbrot.

12 recordsLinked to original sources
PubMed1979

Chronic neutrophilic leukemia. Report of two cases and review of the literature.

Chronic neutrophilic leukemia is a rare, infrequently recognized, myeloproliferative disorder. It usually manifests as a leukemoid reaction, with mostly mature granulocytes in the peripheral blood, with rare to occasional immature forms, and sometimes with normoblasts. The clinical manifestations also include hepatosplenomegaly, elevated leukocytic alkaline phosphatase, elevated serum vitamin B12 and serum vitamin B12 binder ("R" fraction), and elevated serum uric acid. Distinction from a leukemegaly, the absence of sepsis, usually normal erythrocytic sedimentation, and the absence of fever. Leukemoid reactions may be associated with elevated serum vitamin B12 and uric acid, but the levels are usually lower than those found in chronic neutrophilic leukemia. Many patients have gouty symptoms, especially after treatment with Busulfan, and many have an unexplained hemorrhagic tendency, making major operations a risk. The authors add two cases to the 11 previously described.

Adult↗
PubMed1976

Lymphomatoid granulomatosis of the lung, associated with a long history of benign lymphoepithelial lesions of the salivary glands and lymphoid interstitial pneumonitis. Report of a case.

A case of a man who had bilateral benign lymphoepithelial lesions of major salivary glands, subsequently had lymphoid interstitial pneumonitis at the age of 26 years, and progressed to lymphomatoid granulomatosis of the lung at the age of 42 years is reported, A labial gland biopsy was consistent with Sjögren's syndrome, which the patient was clinically suspected of having although his disease lacked many of the classic clinical features of that disorder. There was no evidence of malignant lymphoma of lymph nodes. Immunoglobulin distribances were minor, limited to slightly elevated IgG.

Adult↗
PubMed1976

An evaluation of the Haema-Count MK-40 blood counting system.

The Haema-Count MK-40, a semiautomated blood counting system, determines hemoglobin, erthrocyte count, leukocyte count, and hematocrit values of blood cell suspensions prepared with a small automatic pipetter-diluter. It is similar to the MK-3, which the authors previously evaluated, but has automatic coincidence correlation and a modified prime and rinse cycle. Its performance was compared with those of standard methods, i.e., the single-channel Coulter Counter and manual cyanmethemoglobin and microhematocrit methods. Precisions for hemoglobin determinations and for leukocyte and erythrocyte counts were equal to those of the reference (comparative) methods. Patients comparisons for those determinations had only small intermethod variability and small clinically insignificant biases. The hematocrit channel was the least precise. With a modified method of calibration, the authors obtained patient comparisons without statistically significant bias from the microhematocrit. Calibration was stable for all channels during the course of the study.

Autoanalysis↗
PubMed1975

The effects of therapeutic radiation on colonic mucosa.

Low to moderate doses of therapeutic irradiation are capable of producing bizarre cytologic changes in the mucosal cells of colorectal crypts. This may be associated with eosinophilia of the lamina propria and with eosinophilic crypt abscesses. The bizarre cells generally line intact crypts and do not exhibit invasive behavior. The change subsides within 1-2 months at the dose levels studied (approximately 2000 rads).

Adenocarcinoma↗