Biomedical subjects

I Mäder

Publications and source records attributed to I Mäder.

7 recordsLinked to original sources

PubMed2003

[How are interstitial lung diseases diagnosed in Germany? Results of the scientific registry for the exploration of interstitial lung diseases ("Fibrosis registry") of the WATL].

From 1995 to 1999 we evaluated questionnaires sent by pulmonologists and departments of pulmonology in order to register interstitial lung diseases. On the whole 1142 patients (579 males, 563 females, mean age 51.1 +/- 15.3 years, sarcoidosis, n = 511, extrinsic allergic alveolitis, n = 145, idiopathic pulmonary fibrosis, n = 308, bronchiolitis obliterans organizing pneumonia (BOOP), n = 93, others, n = 85) were recorded in the registry. With reference to the mean age sarcoidosis occurred most frequently in the fourth decade and idiopathic pulmonary fibrosis in the sixth decade. In all these diseases bronchoscopy with bronchoalveolar lavage and transbronchial biopsy was predominantly used for further diagnosis. It was striking that high-resolution computed tomography of the thorax was still rarely used when diagnosing these diseases. Apart from the group with BOOP the number of non-smokers in men and women was decisively higher than the average of the population of Germany.

Biopsy↗

PubMed1999

[CT-assisted transthoracic puncture of pulmonary lesions and mediastinal infiltrations. A retrospective study of 300 patients].

With this retrospective study we evaluated the results and the complications of our 343 CT-guided transthoracic biopsies, which we performed in 300 patients with localised and infiltrative lesions of the lung and the mediastinum during 4 years, using the VacuCut-needle in 96% of our cases. In 256 pts. bronchoscopy without final diagnosis was performed before transthoracic biopsy. In 219 pts. (73.0%) we had positive results. In 209 pts. with malignancies the positive rate was 73.7%. In patients with benign processes the positive rate was less (67.8%). Out of 32 pts, suffering from mediastinal lesions 29 had malignancies. In 79.3% positive results were obtained. The rate of complications was low (9%) in 311 biopsies of pulmonary lesions, most were pneumothoraces (7.7%). Haemorrhages occurred in 4 pts. (1.3%) 5 pts. (1.6%) required drainage because of pneumothorax. On the base of our good results and the low complication rate we recommend CT-guided transthoracic aspiration biopsy with the VacuCut-needle as a useful and accurate diagnostic technique.

Adult↗

PubMed1997

[Tracheobronchomegaly--Mounier-Kuhn syndrome--case report and review of the literature].

Tracheobronchomegaly is a rare disorder. A marked dilatation of the trachea and the main stem bronchi is the characteristic sign measured as an enlarged transverse diameter (mean +/- 3 SD). Bronchiectasis is usual. In about one third of the published cases a diverticulosis was described as demonstrated in one our cases. For diagnostic modern radiological methods (CT including 3 D reconstruction, MRT) and bronchoscopy are recommended. The number and seize of the diverticula are documented by tracheography or by bronchography. In a part of all cases of tracheobronchomegaly the cause of the disorder is known. Therefore a division into congenital and acquired tracheobronchomegaly is useful.

Aged↗

PubMed1988

[Incidence of collagenoses in patients with lung fibrosis].

In 63 out of 887 patients with alveolitis and pulmonary fibroses was causally found a so-called "collagenosis". A participation of the lung in such diseases is prognostically unfavourable. The changes in the framework of the lungs radiographically, functionally and morphologically cannot be separated from fibroses of other origin. The diagnosis is to be made after exclusion of other noxae and taking into consideration the appearances of the primary disease (clinic, spectrum of organs, special laboratory parameters etc.).

Adolescent↗

PubMed1987

[Diagnosis and therapy of nocturnal asthma].

The bronchial tonus depends on circadian oscillations like all other organ functions. The tendency to increased nocturnal bronchoconstriction in some asthmatic subjects is well known. The reasons of such individual variations are different concentrations of cortisol, adrenaline, histamine, cAMP in serum as well as imbalance between vagal and sympathetic interactions. In practice, the early diagnosis of severe nocturnal bronchial constriction is important for prevention of asthma attacks and status asthmaticus. We report on our circadian measurements of airway resistance (Ros) or peak-flow. By adequate therapy an improvement of the individual bronchial tolerance could be achieved, however the biorhythm remained unchanged. Measurements of airway resistance at 2 a.m. were significantly improved by therapy, as was the mean level measurements during 4-hourly readings. High dose bedtime or slow release theophylline decreased the number of nocturnal asthma attacks.

Airway Resistance↗

PubMed1985

[Intrapericardial administration of drugs in the animal experiment].

Intrapericardially supplied agents for instance cardioactive drugs were transferred via lymph vessels in the myocardium likely. In case of dye application the myocardium and also the cardiac valves were coloured additionally. The effect on the heart should be more intensive and faster than after systemic application.

Animals↗

PubMed1985

[Electrically activated blood].

By means of direct current electrically activated blood (EAB) is an endogenous thrombogenic substance. One vessel is occluded permanently by an agglutinative thrombus after injecting such blood. So the thrombosis can be simulated in experiment. In face of the endogenous fibrinolysis EAB proved more resistant than spontaneously coagulated blood and also after adding thrombus in vitro. An iodinated X-ray contrast medium (Visotrast 370) prevents the thrombosis of an artery by EAB.

Animals↗