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Biomedical subjects

I Möller

Publications and source records attributed to I Möller.

At least 19 recordsLinked to original sources
PubMed2006

Gender and socio-economic variations in employment among patients with a diagnosed musculoskeletal disorder: a longitudinal record linkage study in Sweden.

OBJECTIVE: To establish whether the employment consequences of musculoskeletal disorder vary by gender and socio-economic group in Sweden. METHODS: Two linked registers, containing diagnostic and socio-economic data for the 1.8 million residents of Stockholm County, were used to investigate the subsequent employment consequences over 5 yr of having a musculoskeletal disorder requiring hospital admission in 1996. Age-standardized employment rates of all patients with musculoskeletal disorder (n = 2185) were compared with patients employed prior to hospital admission (n = 1286) and with the general population of Stockholm. Odds of leaving employment between 1996-2001 were calculated for men, women and patients from different socio-economic groups. RESULTS: Employment rates increased and social differentials narrowed in the general population, while employment declined and social differentials widened among patients with musculoskeletal disorders. These trends were masked when analyses were restricted to individuals employed at baseline. Following hospital admission, the odds of leaving employment increased annually for patients; by 2001, their adjusted odds were over three times greater [odds ratio (OR) = 3.36, 95% confidence interval (CI) 2.89-3.91] than for the general population. Women with musculoskeletal disorders were significantly more likely to leave employment during follow-up than men (OR = 1.95, 95% CI 1.49-2.56). Semi- and unskilled manual workers with musculoskeletal disorders were over three times as likely to leave employment than their professional counterparts (OR = 3.40, 95% CI 2.41-4.81). CONCLUSIONS: People with musculoskeletal disorders, particularly women and semi- and unskilled manual workers, are vulnerable to leaving employment. Health and social policies must do more to protect the employment of people with musculoskeletal disorders.

Adult↗
PubMed2005

Interobserver reliability in musculoskeletal ultrasonography: results from a "Teach the Teachers" rheumatologist course.

OBJECTIVE: To assess the interobserver reliability of the main periarticular and intra-articular ultrasonographic pathologies and to establish the principal disagreements on scanning technique and diagnostic criteria between a group of experts in musculoskeletal ultrasonography. METHODS: The shoulder, wrist/hand, ankle/foot, or knee of 24 patients with rheumatic diseases were evaluated by 23 musculoskeletal ultrasound experts from different European countries randomly assigned to six groups. The participants did not reach consensus on scanning method or diagnostic criteria before the investigation. They were unaware of the patients' clinical and imaging data. The experts from each group undertook a blinded ultrasound examination of the four anatomical regions. The ultrasound investigation included the presence/absence of joint effusion/synovitis, bony cortex abnormalities, tenosynovitis, tendon lesions, bursitis, and power Doppler signal. Afterwards they compared the ultrasound findings and re-examined the patients together while discussing their results. RESULTS: Overall agreements were 91% for joint effusion/synovitis and tendon lesions, 87% for cortical abnormalities, 84% for tenosynovitis, 83.5% for bursitis, and 83% for power Doppler signal; kappa values were good for the wrist/hand and knee (0.61 and 0.60) and fair for the shoulder and ankle/foot (0.50 and 0.54). The principal differences in scanning method and diagnostic criteria between experts were related to dynamic examination, definition of tendon lesions, and pathological v physiological fluid within joints, tendon sheaths, and bursae. CONCLUSIONS: Musculoskeletal ultrasound has a moderate to good interobserver reliability. Further consensus on standardisation of scanning technique and diagnostic criteria is necessary to improve musculoskeletal ultrasonography reproducibility.

Adult↗
PubMed2004

Infrared diode laser absorption spectroscopy of C(2)H(2) and C(2)H(6) in capacitively coupled methane RF discharges.

Low-temperature RF discharges with methane as feed gas are widely used for the deposition of hydrogenated films. The film properties depend strongly on the chemical composition and therefore two of the main stable products in this kind of discharge, namely ethane (C(2)H(6)) and acetylene (C(2)H(2)), have been measured for the understanding of the reaction kinetics in the plasma. An absorption spectrometer has been built up for the investigation of the concentrations of these as a function of the input power and the flow rate. The time scales for reaching steady state after the discharge is switched on and the depletion time scale after the plasma is switched off have been determined. Assuming the recombination of CH(3) molecules to be the only production mechanism for C(2)H(6) and using a simplified rate equation, the measured densities of C(2)H(6) can be reproduced very well by analytical fitting curves.

Acetylene↗
PubMed2000

YidC mediates membrane protein insertion in bacteria.

The basic machinery for the translocation of proteins into or across membranes is remarkably conserved from Escherichia coli to humans. In eukaryotes, proteins are inserted into the endoplasmic reticulum using the signal recognition particle (SRP) and the SRP receptor, as well as the integral membrane Sec61 trimeric complex (composed of alpha, beta and gamma subunits). In bacteria, most proteins are inserted by a related pathway that includes the SRP homologue Ffh, the SRP receptor FtsY, and the SecYEG trimeric complex, where Y and E are related to the Sec61 alpha and gamma subunits, respectively. Proteins in bacteria that exhibit no dependence on the Sec translocase were previously thought to insert into the membrane directly without the aid of a protein machinery. Here we show that membrane insertion of two Sec-independent proteins requires YidC. YidC is essential for E. coli viability and homologues are present in mitochondria and chloroplasts. Depletion of YidC also interferes with insertion of Sec-dependent membrane proteins, but it has only a minor effect on the export of secretory proteins. These results provide evidence for an additional component of the translocation machinery that is specialized for the integration of membrane proteins.

ATP-Binding Cassette Transporters↗
PubMed1998

Unregulated exposure of the ribosomal M-site caused by NAC depletion results in delivery of non-secretory polypeptides to the Sec61 complex.

Nascent polypeptide associated complex (NAC) interacts with nascent polypeptides emerging from ribosomes. Both signal recognition particle (SRP) and NAC work together to ensure specificity in co-translational targeting by competing for binding to the ribosomal membrane attachment site. While SRP selects signal-containing ribosomes for targeting, NAC prevents targeting of signal peptide-less nascent chains to the endoplasmic reticulum membrane. Here we show that the ribosome binding that occurs in NAC's absence delivers signalless nascent chains to the Sec61 complex, underscoring the danger of unregulated exposure of the ribosomal M-site. Recently, the idea that NAC prevents ribosome binding has been challenged. By carefully examining the physiologic NAC concentration in a variety of tissues from different species we here demonstrate that the discrepancy resulted from subphysiologic NAC concentrations.

Animals↗
PubMed1998

A general mechanism for regulation of access to the translocon: competition for a membrane attachment site on ribosomes.

For proteins to enter the secretory pathway, the membrane attachment site (M-site) on ribosomes must bind cotranslationally to the Sec61 complex present in the endoplasmic reticulum membrane. The signal recognition particle (SRP) and its receptor (SR) are required for targeting, and the nascent polypeptide associated complex (NAC) prevents inappropriate targeting of nonsecretory nascent chains. In the absence of NAC, any ribosome, regardless of the polypeptide being synthesized, binds to the endoplasmic reticulum membrane, and even nonsecretory proteins are translocated across the endoplasmic reticulum membrane. By occupying the M-site, NAC prevents all ribosome binding unless a signal peptide and SRP are present. The mechanism by which SRP overcomes the NAC block is unknown. We show that signal peptide-bound SRP occupies the M-site and therefore keeps it free of NAC. To expose the M-site and permit ribosome binding, SR can pull SRP away from the M-site without prior release of SRP from the signal peptide.

Animals↗
PubMed1983

[Prevention of dental caries in Thailand: 3 fluoridated products submitted for comparative tests].

The aim of a three-year field trial was to compare the relative effectiveness of a 0.2% fluoride rinse used fortnightly, fluoride chewing-gum sweetened with sucrose and fluoride chewing-gum sweetened with a mixture of xylitol and sorbitol (4 sticks of gum chewed per day for 5 days a week during the school year). Indications from the data are that the chewing-gum/sucrose regime was at best considerably less effective than the other two regimes. The study shows that the effectiveness of the chewing-gum/xylitol-sorbitol and the fluoride rinse regimes was comparable.

Adolescent↗
PubMed1979

[Use of the CO2 laser in the treatment of burn injuries].

In the treatment of burn injuries the CO2-Laser has meanwhile proved to be an effective cutting-instrument as well as the Bowie-Knife. A trial-study was carried out in which the necroses were excised simultaneously with the Laser on one side of the body and with the Bowie-Knife on the other. Comparisons were made between blood-loss, time used for escharotomie, injury to the wound bed and post-operative healing of the autograft 4 and 8 days later. The results of the parameter showed that with the Laser there was a reduction in blood-loss of 50% compared with the Bowie-Knife. On the other hand the total operating-time was 1/3 longer, including the time necessary for hemostasis to take place. The blood-loss was measured with a Blood-Loss-Perometer and the result was converted according to the extent of the burned surface area. Histology showed less trauma of the wound bed compared with the Bowie-Knife, rare hemorrhages and inflammatory reactions in Laser so that healing of the autograft proceeded without complications.

Burns↗
PubMed1977

[Course of immunoglobulins G and M in seriously burned patients].

IgM and IgM levels were measured in 108 burn patients. A marked decrease was evident in these immunoglobulins. The initial fall of IgG can be attributed to the loss of serum via the body surface, i.e. burn blisters. The loss of IgM may be taken as indication of the catabolic phase. Quantitative substitution was possible in almost all cases.

Adolescent↗
PubMed1977

[Factor XIII deficiency in burns].

In 34 patients with severe burn injuries platelets, fibrinogen, prothrombin time, partial thromboplastin time, thrombin time and factor XIII were measured daily. Half of the patients were administered 15 000 IE of heparin per 24 hours. In the first 4 days there was a rapid fall of factor XIII to a value of approximately 30%. Values remained very low during the whole observation period of up to 20 days. However, in patients treated with heparin, values tended to be 10--15% higher. After an initial decline on the tenth day, the platelets had risen to the lowest normal level. Platelets were identical in both groups. The causes for the changes in these haemostasis parameters, their significance, and possible consequences of therapy are discussed.

Blood Coagulation Tests↗