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Biomedical subjects

I Mackenzie

Publications and source records attributed to I Mackenzie.

67 records · Page 4Linked to original sources
PubMed1976

Structural deterioration in Celestin tubes.

Two cases are described where, after 2 years, a nylon-latex Celestin tube which was left in situ to bypass a benign stricture underwent structural deterioration and produced complications requiring tube replacement. It is recommended that an alternative endo-oesophageal tube should be considered where a lifespan of this order is contemplated.

Esophageal Stenosis↗
PubMed1976

Selective loss of blood group antigens during wound healing.

Frozen sections of healing wounds of the oral mucosa of 3 rhesus monkeys were examined by a double layer immunofluorescent technic for the presence of blood B-like antigens. Antigen activity was present in normal epithelium and in the epithelial outgrowth into the wounds but was absent from the outgrowth following treatment with lipid solvents. This finding suggests that glycoprotein but not glycolipid associated antigen is lost from the surface of epithelial cells during wound healing, a pattern of selective loss which may reflect a difference between regenerative and neoplastic lesions.

Animals↗
PubMed1975

Condylotomy. A clinical and experimental appraisal of a surgical technique.

211 cases of temporomandibular joint pain/dysfunction syndrome treated by condylotomy were traced. 172 operations were investigated by questionnaire and 119 patients examined clinically and radiographically. Operated patients constituted less than 3% of all patients with the syndrome. 91% were cured or improved by surgery. The anatomical structure involved in the technique and operative complications, are discussed. Principal effects of surgery were to produce an increase in radiographic joint space and shortening of the ramus with minimal long term change in the position of the condylar head from its postoperative position. The clinical findings as regards remodelling were confirmed and investigated histologically in a primate model. The mechanisms of pain production in the temporomandibular joint pain/dysfunction syndrome are discussed.

Animals↗
PubMed1975

Comparative trials of live attenuated and detergent split influenza virus vaccines.

Comparative clinical trials of live attenuated and detergent-split subunit influenza virus vaccines were undertaken with 1048 volunteers in Western Australia. Volunteers were divided into three main groups, each of which received either live virus vaccine or a saline control administered intranasally, or subunit vaccine injected subcutaneously. No differences were recorded between the three groups in their post-vaccination symptoms. Serum samples were collected at various times up to 50 weeks after vaccination, and antibody titres were measured by haemagglutination-inhibition (HI) tests and, for 231 volunteers, by virus neutralization tests. The two vaccines were almost equivalent in inducing seroconversion in vaccinees with pre-trial HI titres of 96 or less, but the subunit vaccine stimulated a higher geometric mean HI antibody titre. The longevity of the HI antibody response was greater for the live virus vaccine. The height of the response and the longevity of neutralizing antibody were the same for both vaccines. Both vaccines provided a high degree of protection against epidemic A/England/42/72 influenza, and some protection against A/Port Chalmers/1/73 influenza.

Adolescent↗
PubMedDate not supplied

Research programs.

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Iowa↗