Biomedical subjects
I Mahé
Publications and source records attributed to I Mahé.
PEP trial. Pulmonary Embolism Prevention.
Explore the source record for details and available documents.
[Multifactorial cardiovascular risk].
IMPORTANCE OF RISK ASSESSMENT: The prevention of cardiovascular disease is a major public health goal. Cardiovascular diseases are the number one cause of mortality in industrialized countries and account for an important part of health care expenditures. In this context, assessment of the cardiovascular risk for a given subject based on epidemiological data and individual risk factors can be used to determine his/her risk of ischemic heart disease or stroke. THE FRAMINGHAM FORMULA: The most widely used assessment method is the Framingham formula which integrates age, sex, blood pressure, smoking habits and presence or not of diabetes. This formula gives an objective, reproducible estimation of the cardiovascular risk and is a useful tool for therapeutic rationale and primary and secondary prevention. INTEREST AND LIMITATIONS: This new global approach to the individual patient has interesting practical and economic implications but remains imperfect due to certain limitations (other risk factors not taken into account because they are difficult to quantify or occurred recently). For daily practice however, it provides a useful tool appreciated by clinicians and patients.
[How long should anticoagulants be administered in the therapy of the first episode of venous thromboembolism?].
Explore the source record for details and available documents.
[Heart failure: an indication for beta blockaders].
Explore the source record for details and available documents.
[What is the role of pravastatin in the secondary prevention of coronary disease?].
Explore the source record for details and available documents.
[Ventricular tachycardia revealing viral myocarditis].
BACKGROUND: The first diagnostic hypothesis in a middle-aged patient presenting with inaugural ventricular tachycardia would be coronary artery disease. If the work-up lacks arguments for this etiology, other cardiac conditions may be involved (dilated cardiopathy, hypertrophic cardiopathy, valve disease arrhythmogenic dysplasia, long QT...). CASE REPORT: A 52-year-old male patient was referred for inaugural ventricular tachycardia. The initial work-up including echocardiography, coronography and the electrophysiologic study provided no explanation. The ventricular tachycardia was later attributed to viral myocarditis. DISCUSSION: Viral myocarditis should always be entertained in patients with unexplained ventricular tachycardia, particular if a viral context is present. In such cases, antibody-labeled scintigraphy is the choice exploration. This noninvasive technique provides determining diagnostic information and helps orient patient management.
[How far should arterial pressure in hypertension be lowered?].
Explore the source record for details and available documents.
[Hospital, occupational health and correction of inequalities in the domain of prevention].
Explore the source record for details and available documents.
Gastroduodenal tolerability of medium dose enteric-coated aspirin: a placebo controlled endoscopic study of a new enteric-coated formulation versus regular formulation in healthy volunteers.
We compared, in a cross-over study, the toxicity of 300 mg enteric-coated aspirin with regular aspirin used for the prevention of cardiovascular events. In terms of endoscopic haemorrhagic lesions, enteric-coated aspirin is less gastrotoxic than regular aspirin.
[Primary cardiovascular prevention: aspirin, vitamin E or placebo].
Explore the source record for details and available documents.
[Quality in health care. What quality? Judged by which criteria? By whom? How?].
Quality in healthcare has to evaluate the efficacy, the cost effectiveness and patient satisfaction. Quality of treatment could be evaluated with randomized clinical trials and with satisfaction measurement, leading to professional recommendations. Quality of therapeutic strategy is based on the evaluation of patient monitoring. The quality of the healthcare worker is based on initial training, accreditation and various audits. The final quality in healthcare depends on the competence of the prescriber but also on the medical information, the logistics and the control of prescriptions. Improvements in quality will be obtained by better medical training, patient information and application of professional recommendations. These recommendations have to change gradually to be adapted to medical progress and evidence-based medicine.