Biomedical subjects
Publications and source records attributed to I Marchenko.
Marker loci in 113 members of nine unrelated multiplex families identified by a bipolar proband were tested for linkages with primary affective disorder. Linkage was excluded between the disease locus (assuming that it was a single autosomal dominant gene) and the HLA loci at a recombination fraction of 0.2, the ABO, Rh, and Lu loci at almost 0.05 and the Fy and P loci at 0.001.
The families of 26 married bipolar manic depressives were examined in detail. The rate of affective disorder in their spouses, and the parents and siblings of their spouses, was ascertained. The prevalence of affective disorder among the parents and siblings and of the spouses of age- and social class-matched schizophrenics and well controls was also ascertained. Finally, the prevalence of affective and other psychiatric disorders in the adult offspring of the bipolar probands was ascertained and related to the presence or absence of affective disorder in the spouse. We did not find clear evidence of assortative mating for major affective disorder, although dual mating for affective disorder had the expected result of increasing the risk for affective disorder in the adult offspring.
Fifty-five of the 58 adult offspring of 17 bipolar manic-depressives were studied. Fifty-three were interviewed and some data were available on the two who had committed suicide. A detailed educational history and pregnancy and birth (paranatal) history were obtained and were corroborated by records where available. Thirty-two percent of the offspring met RDC criteria for major affective disorder, and 13 percent for minor affective disorder. Paranatal and educational problems, separately and together, were not associated with an enhanced risk to affective disorder, however they were significantly associated with an earlier onset to affective disorder. This association may be partly due to a relatively lower IQ among the early onset subjects.
The MMPI profiles of forty suicidal and forty non-suicidal male and female depressed patients, matched for age, were compared. Significant differences between MMPI scale T scores which showed some sex specificity were found between the suicidal and non-suicidal depressives. These results replicate previous findings. However neither individual scale T scores, derived discriminant functions, nor actuarial or cluster analysis-derived MMPI profiles could completely discriminate between suicidal and non-suicidal depressed inpatients of either sex. The relevance and implications of these findings to the ascertainment of suicidal risk are discussed.