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Biomedical subjects

I Marcu

Publications and source records attributed to I Marcu.

7 recordsLinked to original sources
PubMed1979

Erythrocyte rheology in acute cerebral thrombosis. Effects of ABO blood groups.

Within a few hours after a cerebral thrombosis in 220 patients, the flow-properties of the red blood cells (RBC) were analyzed by a filtration test that expresses quantitatively the deformability and aggregability of the RBC by the filtration indexes pT. Abnormal deformability of the RBC washed clean of plasma was found in 27.5% of the patients. Aggregability disorders, caused by the plasma trapped between the unwashed RBC, were found in 78.6% of the patients: computation of correlation coefficients between pT indexes and fibrinogen, which was found abnormally high in 88.2% of cases, demonstrated significantly that in the patients with A and B blood groups these aggregability disorders were due to fibrinogen and that they were caused by other components of plasma in patients with O and AB blood groups. All these disorders can account for blood hyperviscosity.

ABO Blood-Group System↗
PubMed1979

Two cases of choreatic syndrome caused by polycythemia vera.

Two patients with choreatic syndromes caused by polycythemia vera recovered after treatment of the polycythemia by only two venesections: this proves that the syndrome is due to reversible alterations. Investigations of the cerebral circulation in one of the patients showed that blood flow was lowest in the grey matter at the basal region of the brain: this suggests that the alterations might mainly occur there. However, investigation of erythrocyte rheology, glucose-6-phosphate dehydrogenase, serum concentrations of caeruloplasmin and serotonin, and urinary excretion of epinephrine, norepinephrine and vanillylmandelic acid gave normal results in both patients. There are therefore no indications as to the possible pathophysiology of these alterations. There are now 24 cases reported, including our 2 patients, which suggests that the association of these two diseases may not be so rare as supposed.

Adult↗
PubMed1976

Cerebral thrombosis, cerebral haemorrhage, and ABO blood-groups.

The ABO blood-group distributions of 1460 patients who had died from a stroke were compared with those of a control group of 20 705 controls selected at random from the healthy population at risk (i.e., over thirty-five years of age and matched for age and sex ratio). The cause of death was certified as cerebral thrombosis in 329 cases and as cerebral haemorrhage in 482 cases, these diagnoses being established in neurological hospitals; the remaining 649 cases had an unspecified type of stroke, the diagnosis being made by general practitioners. In the group with unspecified type of stroke the blood-group distribution was practically the same as the distribution in the controls. In the thrombosis cases there was an excess of blood-groups A and AB and a deficiency of O and B; in cerebral haemorrhage this situation was reversed. However, these were only trends; the differences were not significant at the 5% level. A statistically significant difference did emerge when the A+AB excess in thrombosis was contrasted with the O+B excess in haemorrhage, suggesting that this difference might be accounted for the major A subgroup (A1) and, consequently, A1B.

ABO Blood-Group System↗
PubMedDate not supplied

Radioisotope investigations in some hemolytic disorders of children.

Ferrokinetics and life-span of erythrocytes were investigated with 59Fe and 51Cr respectively, in 15 children with thalassemia major, aged between 18 months and 15 years (five of which had been splenectomized), and in 8 children with hereditary spherocytosis aged between 12 and 14 years. In all cases studied with 59Fe there was low tracer incorporation in erythrocytes, but no correlation of this parameter to the amount of Hb F. The use of radioisotopes in studies of hemolytic disorders of children is stressed, primarily when splenectomy is considered. Investigation of ferrokinetics in thalassemic children is useful for monitoring advanced stages of the disease.

Adolescent↗