Identification of genes specifically expressed at discrete stages of B-cell development.
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Biomedical subjects
Publications and source records attributed to I McDermott.
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A survey has shown that peri-operative antibiotic therapy was inappropriate in 83% of patients undergoing abdominal or arterial surgery. Missed doses at induction or postoperatively, a questionable choice of antibiotics and unnecessarily long postoperative courses were major problems. The introduction of formal guidelines was partially successful with appropriate prescribing improving from 17 to 60% of cases. There was, in addition, a marked reduction in prescribing costs.
Modern therapeutic modalities and emphasis on early detection have made oral cancer a treatable, and in many cases, a curable disease. The role of the dentist in cancer patient management is two-fold. Early detection of oral lesions during routine dental examination has been shown to be a significant factor in cancer diagnosis. The dentist's other role comes after cancer treatment, specifically therapeutic radiation. Ionizing radiation can have permanent effects on both hard and soft tissues. Prescription and use of fluoride gel in topical applicators can aid in assuring oral health for post-cancer patients.
Patients with chronic respiratory insufficiency resulting from paralysis of respiratory muscles have been supported most commonly by mechanical ventilation via a tracheostomy. Acute and long-term morbidity and mortality have been associated with tracheostomy. Noninvasive alternatives for providing mechanical respiratory support include negative pressure "body ventilators" and positive pressure ventilation via a nasal, oral, or oronasal interface. Intermittent positive pressure ventilation via the nose, mouth, or oronasal combination is effective and convenient for the majority of patients when the interface is sufficiently airtight and comfortable to permit effective long-term use. Construction of custom-fabricated interfaces for the administration of assisted ventilation is presented. These interfaces provide better fit for greater interface seal and comfort than commercial masks. They allow more patients to benefit from assisted positive pressure ventilation in the home without resorting to a tracheostomy.
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