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Biomedical subjects

I Mendizov

Publications and source records attributed to I Mendizov.

17 recordsLinked to original sources

[2 cases of malignant insulinoma of the pancreas].

Two cases are reported of malignant insuloma: in one of the patients the tumor was hormonally active in the other inactive. Treatment was operative. The great difficulties in establishing the diagnosis preoperatively and the complications accompanying this grave disease are pointed out. The clinical and laboratory examinations which may help to reach at the correct diagnosis are discussed.

Adult

[Thoracophrenotomy in adrenal surgery].

The approaches to the adrenal gland may generally be classified into three groups abdominal, lumbar and thoracic. Thoracophrenotomy is one of them, which is used in the surgical treatment of diseases of the adrenal gland. The approach has a series of advantages over the other conventionally used ones; this is confirmed by the good results obtained with its application in 21 operated patients.

Adrenal Gland Diseases

[A combination of ectopic parathyroid adenoma and thalassemia with manifestations of extreme hyperparathyroidism].

A case is presented of a woman with primary hyperparathyroidism due to a parathyroid adenoma with deep mediastinal localization successfully treated surgically. The disease was manifested at the beginning with joint pains only, followed by extreme bone, renal and metabolic disorders endangering the life of the patient. The unusually severe sceleton decalcification is linked with the functional exhaustion of the calcitonin C producing cells. The changes in these cells in the resected thyroid tissue were discrepant with the hypercalciemia. A special feature of the case is the combination of parathyroid adenoma with a number of dysmorphic signs, with a persistent thymus and beta-thalassemia (heterozygotic form) with familial predisposition--thalassemia of the mother and malformations of the patient's child. On this basis the authors presume a genetic determination of the basic disease similar to other forms of primary hyperparathyroidism.

Acute Disease

[Case of Hashimoto's toxicosis with occult thyroid carcinoma].

A female patient, aged 39 is described, with enlarged thyroid gland since childhood, who developed, within 6 months, the clinical picture of Basedow's disease, pretreated with thyrostatics and operated. The histological study revealed an occult thyroid carcinoma in combination with histopathological changes, characteristic for struma Basedowificata and lymphocytic thyroidits of Hashimoto. No similar coincidence of those diseases of thyroid gland is available in literature.

Adenocarcinoma