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Biomedical subjects

I Mortensen

Publications and source records attributed to I Mortensen.

24 records · Page 2Linked to original sources
PubMed1980

Combined effect of benzylpenicillin and gentamicin/netilmicin on Streptococcus faecalis.

The 50% inhibitory concentrations (IC50) of gentamicin and netilmicin were determined for 55 clinical isolates of Streptococcus faecalis, approximately half of which were recovered by culture of blood samples from patients with endocarditis. The IC50 for gentamicin was less than 5 micrograms/ml for 22 strains and less than 40 micrograms/ml for all strains, and for netilmicin the IC50 was less than 5 micrograms/ml for 51 strains and less than 40 micrograms/ml for all strains. Eight out of the 55 strains were found to have IC50 values greater than 10(4) micrograms/ml for streptomycin (3). The bacterial effect of combinations of benzylpenicillin and gentamicin or netilmicin was studied in 19 strains of S. faecalis which represented different levels of resistance to streptomycin. Netilmicin was as effective as gentamicin in combination with benzylpenicillin against all strains.

Dose-Response Relationship, Drug↗
PubMed1977

Effect of combinations of penicillin and aminoglycosides on Streptococcus faecalis: a comparative study of seven aminoglycoside antibiotics.

The 50% inhibitory concentrations (IC50) of benzylpenicillin, streptomycin, sisomicin, gentamicin, tobramycin, kanamycin, amikacin, and butirosin were determined for 58 clinical isolates of Streptococcus faecalis, 28 of which were recovered from cultures of blood samples from patients with endocarditis. The IC50 of streptomycin was less than 100 microng/ml for 42 strains, 192-10,000 microng/ml for eight, and larger than or equal to 10,000 micron/ml for eight. One isolate that was highly resistant to streptomycin was also highly resistant to kanamycin and butirosin. Extraordinarily high resistance to the other aminoglycosides was not observed. The bactericidal effects of combinations of penicillin and aminoglycosides were studied in 20 strains of S. faecalis that represented different levels of resistance to streptomycin. Significant enhancement of the effect of the combination of penicillin and streptomycin was found only in strains with an IC50 of smaller than or equal to 190 microng/ml. Combinations of penicillin and sisomicin, gentamicin, or tobramycin were effective even against strains that were highly resistant to streptomycin and kanamycin.

Amikacin↗
PubMedDate not supplied

Effects of long-term exposure to trichloroethylene on the behavior of Mongolian gerbils (Meriones unguiculatus).

Two groups of Mongolian gerbils (Meriones unguiculatus) were continuously exposed to 150 ppm trichloroethylene (TCE) for 71 and 106 d, respectively. The behavior of the animals was tested in a symmetrical maze baited with sunflower seeds during a period of 23 d, beginning at the end of exposure. One additional group was exposed for 150 d and then allowed 40 d free from exposure before the start of the maze test. Comparisons between the TCE- and air-exposed animals showed differences in the number of correct choices and the number of seeds consumed in the maze, both after 71 and 106 d of exposure and at the end of the 40-d rehabilitation period that followed the 150-d exposure. The results were interpreted in terms of the "emotionality" of the animals.

Animals↗