Biomedical subjects

I Mucska

Publications and source records attributed to I Mucska.

3 recordsLinked to original sources

PubMed2003

On the origin of cardiovascular complications of sleep apnea syndrome by the means of molecular interactions.

In this article we present a novel hypothesis of the pathogenesis of cardiovascular complications of sleep apnea syndrome (SAS). Chronic intermittent hypoxia occurring in association with SAS represents a variation of chronic ischaemia reperfusion injury of the heart. In the hypoxic cells hypoxia inducible factor induces adaptation processes, including production of vascular endothelial growth factor and suppression of antioxidative mechanisms. Resulting oxidative and carbonyl stress are responsible for endothelial dysfunction leading to the development of systemic hypertension. Metabolic and vascular changes stimulate the atherogenic process. Besides the pathogenetic pathway of cardiovascular complications of SAS, we also present the latest concluding results from experimental observations and epidemiological studies concerning sleep disordered breathing and diseases of heart and vessels. Our theoretical assumption should be further proved.

Cardiovascular System↗

PubMed2000

[Primary pulmonary hypertension].

Authors described a case of 26-year old patient with history of progressing dyspnea and repetitive syncopes. In history is intermittent hemoptysis and dyspnea from 1990. Diagnosis of thromboembolic disease was suspected. Clinical picture was dominated by dyspnea, central cyanosis, sinus tachycardia without pulmonary signs of hearth failure. On ecg there is right heart hypertrophy. Echocardiographic examination shows dilatation of right heart, systolic pressure in a. pulmonalis about 90 mmHg and tricuspidal regurgitation of the III. degree. Phlebothrombosis was not found. Complete hemocoagulation examination excluded a primary procoagulating hematologic disease. Pulmonary angiography did not confirm thromboembolic disease but found a high grade pulmonary hypertension--mean pulmonary arterial pressure of 93 mmHg. After complex pneumological examination, including HRCT, and other examinations the diagnosis of primary pulmonary hypertension was made. Patient is indicated to lung transplantation. (Fig. 4, Ref. 9.)

Adult↗

PubMed2000

[The sleep apnea syndrome in the Slovak Republic].

Sleep related breathing disorders represent life threatening disorders for cardiovascular and neuropsychiatric complications. Sleep apnea syndrome is evaluated in Slovak Republic since 1990. Four sleep laboratories are established with polysomnography ALICE 3. 628 investigations together were realized till March 31, 2000. Except diagnostic and therapeutic area our interest is focused on cardiovascular complications. Ventilatory treatment of patients with sleep apnea syndrome is insufficiently provided by health insurance companies.

Health Facilities↗