Biomedical subjects

I Musevic

Publications and source records attributed to I Musevic.

At least 19 recordsLinked to original sources

PubMed2006

Colloids on free-standing smectic films.

We study the structure of a free-standing smectic-A film around a micron-size polystyrene colloid adsorbed onto the film. We find that a colloid or a cluster of colloids is surrounded by an optically distinct and radially decorated meniscus ending with a sharp edge. The observed strong and finite-range attraction between the adsorbed colloids is driven by the fusion of menisci. We interpret the structure of the smectic meniscus in terms of a model dominated by the surface free energy and we argue that the characteristic appearance of the meniscus is due to layer undulations.

Adsorption↗

PubMed2006

Anisotropic laser trapping in nematic colloidal dispersion.

The interaction between a colloidal particle and a focused laser beam in a nematic liquid crystal reveals an unusual anisotropic Coulomb-like character. Experiments demonstrate two opposite directions in which the particle is attracted to and repelled from the nematic region deformed by the light-induced director reorientation. In this work we present analytical analysis of such behavior and derive the energy of interaction between colloidal particle and deformed director field. The analytical solution is in good agreement with recent results obtained by computer simulation.

Colloids↗

PubMed2006

Laser trapping of low refractive index colloids in a nematic liquid crystal.

We describe and analyze laser trapping of small colloidal particles in a nematic liquid crystal, where the index of refraction of colloids is smaller compared to the indices of the liquid crystal. Two mechanisms are identified that are responsible for this anomalous trapping: (i) below the optical Fréedericksz transition, the trapping is due to the anisotropic dielectric interaction of the polarized light with the inhomogeneous director field around the colloid, (ii) above the optical Fréedericksz transition, the optical trapping is accompanied by the elasticity-mediated interaction between the optically distorted region of a liquid crystal and the colloid. In the majority of the experiments, the trapping above the Fréedericksz transition is highly anisotropic. Qualitative agreement is found with a numerical analysis, considering the nematic director elastic distortion, dielectric director-light field coupling and optical repulsion due to low refraction index colloid in high index surroundings.

Journal Article↗

PubMed2005

Test of clock model in ellipsometric study of thin and thick free-standing films of an antiferroelectric liquid crystal.

The temperature dependences of the ellipsometric parameters in a weak dc external field are studied in thin and thick free-standing films of MHPOBC. The results for thin films consisting of two, three, and four layers are analyzed within the discrete phenomenological model. We find very good quantitative agreement between the theory and experiment, which indicates an odd-even effect. We find that the XY structures are stable for an odd number of layers, whereas planar, Ising-like structures are stable for an even number of layers. The experiments on thick (several tens of layers) films show a combination of bulklike and free-surface behavior. This is most pronounced at high temperatures, where the interior of the film is not tilted, whereas the layers at the air interfaces show qualitatively similar temperature dependance of the ellipsometric parameters as in the four-layer film.

Journal Article↗

PubMed2005

Atomic force microscope study of presmectic modulation in the nematic and isotropic phases of the liquid crystal octylcyanobiphenyl using piezoresistive force detection.

Using a temperature controlled atomic force microscope (AFM), we have studied surface induced pre-smectic order in the nematic and isotropic phases of 4-cyano- 4'-n -octylbiphenyl. A modified AFM head with piezoresitive cantilevers has been used to measure the structural force between a flat BK7 glass plate and a 10 microm glass sphere, both being treated to induce homeotropic alignment of the confined liquid crystal layer in between. We have observed surface-induced presmectic force not only in the isotropic, but also in the nematic phase. We have measured the temperature dependencies of the presmectic force, the smectic correlation length xi and the smectic order parameter psi at the surface. The correlation length xi(T) shows a power-law temperature dependence with a critical exponent of nu=0.67 +/- 0.03 and the bare correlation length of xi(0) = (0.39 +/- 0.08) nm, in good agreement with x-ray data. The smectic density at the surface is psi(2)(S) =0.4 in the nematic phase and decreases in the isotropic phase.

Journal Article↗

PubMed2004

Structures and phase transitions in thin free standing films of an antiferroelectric liquid crystal.

The premises of a discrete mean-field model for polar smectic liquid crystals are tested by analyzing the ellipsometric experiments on two, three, and four-layer freestanding films of MHPOBC. The measured temperature dependences of the ellipsometric parameters in a weak dc external field are compared to the predictions of a simple clock model. A very good quantitative agreement is found indicating an odd-even effect: XY structures are stable for odd and Ising-like structures for an even number of layers.

Computer Simulation↗

PubMed2004

Laser trapping of small colloidal particles in a nematic liquid crystal: clouds and ghosts.

We show that, contrary to intuition, small (< or =1 microm) transparent particles can be trapped and manipulated in a nematic liquid crystal using an intense laser beam, although their index of refraction is lower than both refractive indices of the surrounding birefringent fluid. Two mechanisms are identified that are responsible for this anomalous trapping: (i) surface-induced distortion of the birefringent media around the particle, creating a high-index "cloud" around the colloid, and (ii) laser-induced distortion or (partial) melting of a nematic, creating a ghost colloid.

Journal Article↗

PubMed2003

Capillary forces in a confined isotropic-nematic liquid crystal.

We have investigated nematic capillary condensation in the isotropic phase of nematic liquid crystals 5CB (4-cyano-4(')-n-pentylbiphenyl) and 8CB (4-cyano-4(')-n-octylbiphenyl) confined to nanometer thick layers between two orienting surfaces. The capillary condensation was induced by decreasing the liquid crystal layer thickness using an atomic force microscope, and the onset of condensation was detected by monitoring the structural force on a confining surface. Very strong and long-ranged capillary forces were observed at temperatures close to the isotropic-nematic transition. We have analyzed the temperature dependence of the thickness of the liquid crystal layer, at which the condensation occurs, with a thermodynamic Kelvin equation and determined the interfacial tension between the isotropic and nematic phases. The separation dependence of capillary forces was analyzed within the Landau-de Gennes approach, including electrostatic interaction due to surface charging. The quantitative agreement between the measured and calculated force profiles is very good, and a single set of parameters is needed to describe a set of measured force profiles at different temperatures. Surface charge density, surface potential, and Debye screening length were determined directly from the observed surface forces.

Biophysical Phenomena↗

PubMed2003

Structure and polarity of 8CB films evaporated onto solid substrates.

Brewster-angle reflection ellipsometry and surface optical second harmonic generation were used to study the growth of 4'-n-octyl-4-cyanobiphenyl (8CB) films evaporated in air onto polymeric and quartz glass substrates. The layer-by-layer growth of the films terminates after formation of two distinctive interfacial layers. Both of these two layers are polar and tilted. In the first layer the molecules lie nearly flat on the surface, while in the second layer they point on average about 50 degrees toward the surface normal. The dipole moment of the second layer has a lower magnitude and an opposite direction with respect to the dipole moment of the first layer.

Journal Article↗

PubMed2002

Structure and dynamics of freely suspended film of the smectic-C*alpha phase in an external transverse electric field.

We present a theoretical analysis of static and dynamic properties of freely suspended films of the smectic-C*alpha phase in an external electric field, applied along the smectic layers. The analysis is performed within the "clock" model, where the interactions up to next-nearest neighbors are considered. The calculated critical electric field for the unwinding of the smectic-C*alpha phase is of the order of several 100 V/mm and strongly depends on the interlayer interactions. The calculated relaxation rates of the eigenfluctuations of a system of N layers are in the kilohertz range for phase fluctuations and several megahertz for amplitude fluctuations.

Journal Article↗

PubMed2002

Observation of an electrostatic force between charged surfaces in liquid crystals.

We report on the atomic force microscope observation of an electrostatic force between glass surfaces immersed in cyanobiphenil liquid crystals. The measured force is repulsive and decays exponentially with increasing surface separation. A mean field description of the electrostatic interaction in liquids has been used to determine the Debye screening length, the concentration of dissolved ions, and the surface electric potential. The effect of the observed interfacial electric field on the liquid crystal orientation at the surface has been discussed. It has been found that the coupling between the liquid crystal order and the surface electric field does not contribute considerably to the surface orienting action.

Journal Article↗

PubMed2002

Surface-induced nematic and smectic order at a liquid-crystal-silanated-glass interface observed by atomic force spectroscopy and Brewster angle ellipsometry.

We have investigated nematic and smectic surface-induced ordering in the isotropic phase of the 4-cyano-4'-n-octylbiphenyl liquid crystal on silanated BK7 and LaSF glass using atomic force spectroscopy and Brewster angle ellipsometry. We have observed complete wetting of the silanated glass surfaces with the nematic phase when approaching the isotropic-nematic phase transition from above. Using the atomic force spectroscopy at the same interfaces, we have detected a significant presmectic ordering that is enhanced at the nematic-isotropic transition. We have observed the first, strongly adsorbed layer of liquid-crystalline molecules underneath this presmectic ordering. This first molecular layer is laterally inhomogeneous with typically 100 nm voids and covers approximately 70% of the surface. It is stable far above the clearing point and is responsible for the surface-memory effect. The results have been analyzed using Landau-de Gennes theory. The surface coupling energies of the nematic and smectic order have been determined, as well as the coupling energy between the nematic and smectic order.

Journal Article↗

PubMed2001

Forces in the isotropic phase of a confined nematic liquid crystal 5CB.

Using a temperature controlled atomic force microscope, we have measured the temperature dependence of the force between a flat silanated glass surface and a silanated glass microsphere, immersed in the isotropic phase of the nematic liquid crystal 5CB (4'-n-pentyl 4-cyanobiphenyl). At separations of several nanometers, we observed a weak, short range attractive force of the order of 100 pN, which was increased by decreasing the temperature. The temperature dependence of the amplitude and the range of this attractive force can be described by a combination of van der Waals and a mean-field prenematic force due to the surface-induced nematic order. This is supported by ellipsometric study and allows for the determination of the surface coupling energy of 5CB on a silanated glass surface.

Journal Article↗

PubMed2001

Optical rotation and structure of ferrielectric smectic phases.

We analyze the measured optical rotation in three- and four-layer smectic ferrielectric phases within the matrix approach to the light propagation. We show that "perfect" three- and four-layer structures with 120 degrees and 90 degrees phase rotation of the director in neighboring layers give negligible optical rotation of polarized light travelling along the normal to the smectic layers. Significant optical rotation is obtained in deformed three- and four-layer smectic phases. The analysis of the measured optical rotatory power clearly shows that three-layer ferrielectric phases of [4-(1-methylheptyloxycarbonylphenyl)-octylbiphenyl-4-carboxylate] and 4-[(4-[[1(*)-methyl]heptycarboxy]phenyl)carboxy]phenyl-4'-decyloxy-1-benzencarbatioate (10OTBBB1M7) are deformed with the deformation angle of 35 degrees-45 degrees. The deformation angle in the four-layer smectic phase of 10OTBBB1M7 is 70 degrees-90 degrees. This is in reasonable agreement with other experiments and suggests the validity of the "deformed clock model."

Journal Article↗

PubMed2001

Capillary condensation of a nematic liquid crystal observed by force spectroscopy.

We have observed capillary condensation in nanometer-thin films of nematic liquid crystals using force spectroscopy. The liquid crystal was confined to a submicron gap between a flat substrate and a microsphere, attached to the cantilever of an atomic force microscope. A long-ranged and strongly attractive force due to capillary condensation of a nematic phase was observed at temperatures close to the bulk isotropic-nematic phase transition. The critical point, terminating the first-order confined isotropic-nematic transition line, was determined for the first time.

Journal Article↗

PubMed2001

Investigation of the felodipine glassy state by atomic force microscopy.

The glassy state of felodipine was prepared by melting crystals of felodipine on a clean glass slide and cooling to room temperature. It has been confirmed that glassy felodipine is a metastable state, and undergoes transformation to the more stable crystalline form. Crystallization occurred slowly and spontaneously at room temperature, below the glassy state transition temperature (Tg). The contact mode of atomic force microscopy was used for topographical imaging of the glassy and crystalline states of felodipine. When the glassy felodipine region next to the recrystallized zone was exposed to controlled mechanical stress through the tip, rapid additional crystallization was observed. This crystallization process can be induced and imaged in real time by atomic force microscopy.

Calcium Channel Blockers↗

PubMed2000

Atomic force microscope evidence for the existence of smecticlike surface layers in the isotropic phase of a nematic liquid crystal

Using a temperature controlled atomic force microscope we have observed presmectic layering in the isotropic phase of 4-cyano-4(')-n-octylbiphenyl (8CB) on silanated glass. The first molecular layer shows a smecticlike compressibility modulus of B approximately 10(7) N/m(2) and is stable more than 20 K beyond the bulk clearing point. It is followed by a presmectic modulation that increases when cooling towards the isotropic-nematic transition. In the bulk isotropic phase, the layers cover approximately 70% of the glass surface, indicating a clusterlike organization.

Journal Article↗

PubMed1999

AFM imaging of surface adsorbed polymeric 3-alkylpyridinium salts from the marine sponge Reniera sarai.

Bioactive 3-alkylpyridinium polymers (poly-APS) have recently been isolated from the marine sponge Reniera sarai. Previous results have shown that these molecules in aqueous solutions form supramolecular aggregates with an average hydrodynamic radius of 23 +/- 2 nm. To obtain additional evidences about the shape and the dimensions of poly-APS aggregates, we used atomic force microscopy (AFM) operating in tapping mode. The images clearly showed adsorbed aggregates with a lateral dimension of approximately 40 nm and a thickness of the order of approximately 1 nm. The distribution of volumes of the adsorbed aggregates is very similar to the distribution of hydrodynamic radii as obtained from the dynamic light scattering experiments. The volume distribution of these aggregates shows a maximum at 1750 nm3, which corresponds to a sphere with a radius of 7.5 nm.

Adsorption↗