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Biomedical subjects

I N Bogomolova

Publications and source records attributed to I N Bogomolova.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Morphometric approaches to diagnosing the time of death].

A new method has been used to evaluate the time of death. The relationship between the degree of autolysis of cadaveric viscera and time of death has been studied by histomorphometrical methods. The study was carried out on histological preparations of the lungs, heart, liver, spleen, and kidneys from 20 corpses of humans dead from craniocerebral injuries. Based on the results, tables were created for evaluating the time of death even at remote periods after death, when the results of other methods are unreliable.

Forensic Medicine↗
PubMedDate not supplied

[Role of alcoholization in pathogenesis of morphological changes in substance abusers].

Morphological manifestations of combined intoxication with ethanol and narcotics are described. Special attention is paid to changes in the liver which were studied both qualitatively and quantitatively. Specific features in the pathological processes concomitant with combined intoxication are described; high incidence and expression of morphological markers of alcoholism in subjects abusing both ethanol and narcotics in comparison with "pure" alcoholics were determined. These features can be used in forensic medical and pathological (autopsy) diagnosis of chronic narcotic intoxication and its combination with alcoholism.

Adolescent↗
PubMedDate not supplied

[Forensic-medical evaluation of the histologic structure of the hymen].

Variants of microscopic structure of the hymen are described and its histological classification based on the stromal component structure is offered. Hypotheses on the hymen histogenesis under different conditions are formulated. Histological analysis and histological classification of the hymen are needed for objective solution of questions arising during expert evaluation of virginity and its violation, probability or improbability of coitus without defloration.

Adolescent↗
PubMedDate not supplied

[Use of liver morphometry in the differential diagnosis of chronic alcohol and narcotic poisoning].

Data on the quantitative histomorphological involvement of the liver in chronic narcotic and ethanol poisoning and their combination are presented. Alcohol use by narcomaniacs augments hepatocyte damage, which manifests by increased fatty degeneration, increased activity of lobular hepatitis, appearance of the neutrophil admixture in inflammatory infiltration, and stimulation of sclerotic processes leading to an increase in the perimeter of portal tract section at the expense of connective tissue growth. Quantitative analysis of these processes is recommended for forensic medical histological differential diagnosis of chronic narcotic and ethanol poisoning.

Chronic Disease↗
PubMedDate not supplied

[Age-specific changes in bone tissue microstructure and potential for use for human identification].

The possibility of using the data of quantitative microscopy of bone tissue for evaluation of age with the aim of personality identification is discussed. Computer histomorphological analysis of third rib, tibial lower epiphysis and diaphysis fragments from 564 male corpses of known age (0-90 years) was carried out. A complex of parameters most strongly correlating with age was detected: extension of active osteogenesis zone in the longitudinal section of a rib, thickness of layers of internal and external general diaphyseal laminae in the tibial bone, trabecular area in the tibial epiphyseal preparation, etc. Age-specific changes in bone tissue structures is characterized by a great variety and depends on the type and location of these structures. Bone tissue characteristics change irregularly and asynchronously, therefore their correlations with age are different in different age groups. A general biological interpretation of the results is offered.

Adolescent↗
PubMedDate not supplied

[Thanatogenesis variants in drug use poisoning].

The study of 179 autopsy cases of narcotic poisoning has distinguished four main types of tanatogenesis, the "brain death" being most frequent. The second type was tanatogenesis by type of "sudden cardiac death" with ventricular fibrillation. The third one is tanatogenesis by type of "toxic edema of the lungs" with severe respiratory failure. Rare types of tanatogenesis were acute adrenal failure, anaphylactic shock and others. Combination of several tanatogenesis types was frequent.

Adrenal Glands↗
PubMedDate not supplied

[Forensic medical evaluation of the morphological alterations of the liver in drug abuse].

Application of a morphometric method for investigation of chronic virus hepatitis in drug addicts and persons rejecting drug abuse is described. Chronic hepatitis in narcomania runs with frequent formation of lymphoid follicules in the portal tracts, relatively inactive portal hepatitis in marked lobular component of inflammation, pronounced fibrosis and early formation of micronodular hepatic cirrhosis, proliferation of biliary ducts, high neutrophil, eosinophil and macrophage content in the infiltrate, accumulation of macrophages in the portal tracts by granuloma type. These criteria are recommended for diagnosis of narcomania by morphological findings.

Adolescent↗
PubMedDate not supplied

[Forensic and medical evaluation of vascular malformations of the brain in cranio-cerebral trauma].

A classification of vascular malformations (VM) is defined in the article including a differentiation between their macroscopic and histological variations; an independently-authors-observed case of arterial-and-venous malformation (AVM) in a minor cranial-cerebral trauma (CCT) is described. Published data reflecting the forensic-and-medical value of AVM and cavernous malformations as well as of telangectasias and of arterial-and-venous fistulas in minor head traumas are analyzed. Issues of the forensic-and-medical expertise of VM and remote consequences of CCT are under consideration. VM are assessed in CCT patients with epilepsy and other pathologies. An algorithm of the forensic medical expertise of VM is suggested.

Adult↗
PubMedDate not supplied

[Pathomorphological manifestations of various forms of alcohol disease].

In acute poisoning with ethanol a cardiac variant of tanatogenesis prevails. Signs for ethanol surrogates of DIC syndrome are more characteristic. Alcohol cardiomyopathy and liver cirrhosis are typical as causes of death for chronic forms of alcoholic disease. Histochemical features in the brain are found characteristic for some forms of alcoholic disease.

Adolescent↗
PubMedDate not supplied

[The forensic medical significance of morphometry of the spleen in drug addiction and chronic alcoholic intoxication].

Data on histomorphologic damage to the spleen in chronic narcotic and alcoholic intoxication are described. The below features are recommended for the diagnosis of chronic exogenous intoxication: thickening and sclerosis of the spleen connective structures and a lower count of lymphocytes in the white pulp. The diagnosis criteria of chronic intoxication by intravenously administered opiates are: hyperplasia of the spleen follicles as well as a higher quantity of plasmocytes and of eosinophiles in the white pulp. Hypotrophy of the spleen lymphoid follicles and higher counts of monocytes and macrophages in the lymphoid follicles should be also regarded as a sign of chronic alcoholic intoxication. The obtained data can be used by forensic medical experts in the diagnosis of chronic narcotic intoxication and in its differential diagnosis versus alcoholic intoxication.

Adolescent↗
PubMedDate not supplied

[Morphological features of chronic viral hepatitis in drug addicts].

Liver pathology in parenteral drug abusers (PDA) was studied morphometrically. Chronic hepatitis in PDA is characterized by high incidence of lymphoid follicles formation in the portal tracts and intralobularly, relatively low activity of portal hepatitis in significant expression of the lobular component of the inflammatory process, marked fibrosis and early formation of micronodular liver cirrhosis, noticeable proliferation of narrow bile ducts, high content of neutrophils, eosinophils, siderophages and common macrophages in the infiltrate and their granuloma-like accumulations in the portal tracts. These criteria are recommended for diagnosis of drug abuse by morphological data. The use of a morphometrical method is proposed for studying morphological manifestations of chronic hepatitis, for perfection of their classification, in particular.

Adolescent↗