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Biomedical subjects

I N Borisov

Publications and source records attributed to I N Borisov.

At least 19 recordsLinked to original sources
PubMed1987

[Characteristics of intrarenal ampicillin distribution in chronic pyelonephritis in children].

Pharmacokinetics and characteristic features of ampicillin kidney distribution were studied in 21 children with chronic pyelonephritis without signs of renal insufficiency who had undergone urological operations. It was found possible to provide the antibiotic concentrations efficient against ampicillin sensitive and partially middle sensitive microorganisms in the renal parenchyma, pelvis wall, ureterocele, megaureter and urinary bladder. Ampicillin concentrations in tissues of the urinary system were shown to correspond to a higher extent to the concentrations attained in blood than those in urine.

Ampicillin↗
PubMed1987

[Effect of the serum of alcoholics on the growth of primary cultures human fetal liver cells].

The study has aimed at ascertaining the role of the "serum factor" of alcoholism, the mechanism of its action on the development of liver lesions and morpho-functional properties of liver cells in alcoholics. The results obtained point to significant qualitative peculiarities of the growth of hepatocyte culture in the presence of alcoholics' serum which are expressed in suppression of liver cells and stimulation of white blood cells. The development of alcohol-related hepatic lesion (AHL) is known to be attended by mobilization of immunological mechanisms which is confirmed by the high lymphocytic activity in the considered model. Other leading signs of AHL is dystrophy of hepatocytes and proliferation of connective tissue which also manifests in a scissors-like difference in the growth of epithelium-like and fibroblast-like cells.

Adult↗
PubMed1985

[Features of liver lesions in experimental alcoholism in young animals].

A comparative evaluation of the morphohistochemical changes in the liver in adult and young animals following a two-month alcohol intoxication revealed the following changes in the younger animals: the absence of lymphocytic-macrophagal infiltrates, a larger number of binuclear cells and the appearance of large amounts of lymphocytes with a marked positive reaction to alkaline phosphatase.

Acid Phosphatase↗
PubMed1984

[Characteristics of the brain lesion in experimental alcoholism in young animals].

Morphohistochemical changes in the cortical structures were studied comparatively in 56 adult and young rats during two-month alcoholization and after its discontinuation. It was demonstrated that in young animals, both compensatory processes and signs of damage were more pronounced, with various cerebral components reacting differently. Thus, the neuronal bodies displayed little change while there were marked impairments in their axons. Young animals exhibited greater vascular damage whereas their glial reaction was on the contrary more adequate to experimental conditions. Nevertheless, young animals in our model experiments showed no irreversible impairments in their cerebral cortex which could be indicative of the malignancy of juvenile alcoholism. In short-term temporary alcohol intoxication, the morphofunctional resources of the cortex can recover completely following ethanol withdrawal. Evaluating the alterations detected in the cortical nerve tissue, it appears reasonable to classify them as a manifestation of the morphohistochemical constituent of the multi-level protective compensatory syndrome in alcoholism.

Aging↗
PubMed1980

[Debatable questions in the theory of parenchymella].

Certain variants of the theory are compared. As the precursors of parenchymella Mechnikov's blastea, Lang's blastea, amphiblastea, homogenous parenchymella were supposed. The parenchymella could be formed either via multipolar or unipolar immigration of blastodermal cells. It is not clear whether the differentiation of the parenchymal cells took place before or during their immigration. The initial-parenchymal structure of Metazoa evidences in favour of a divergent differentiation and not the immigration of the external and internal cells. In order to evaluate further evolutional ways of the parenchymella, it is important to notice that there are no specialized digestive cells in the parenchyma of calcareous sponges and that endomesodermal myocytes in lower invertebrates are similar to myoepithelial cells. The theory of genitogastrea is discussed. It is noted that the genitoparenchymella should be considered as the precursor of the genitogastrea. Preliminary calculations have demonstrated that small genitoparenchymellas could be stable, and when the genitoparenchymella is formed from the blastea, including more than 10,000 cells, it is possible that the parenchymella is converted into the genitoblastea much more quickly. Weak points and possible suggestions of Zakhvatkin's theory on the origin of Metazoa from metagenetic protists are discussed.

Animals↗
PubMed1978

[Reciprocal homology of the preotic mesodermal segments of representatives of different classes of vertebrates].

The data of the literature and those of the author on the origin of preotic mesodermal segments are discussed. Only in Cyclostomata all preotic segments are formed from the wall of archenteron and are larval segments. In all the gnathos tomata, the primary gastral segments are substituted, to different degrees, by postlarval peristonal mesoderm. The preotic mesomeres of Cyclostomata are homologous to II--IV mesomeres of Branchiostoma lanceolata. The anterior cephalic cavity and the premandibular segment of the elasmobranchia are homologous to I and II segments of Branchiostoma lanceolata. The mandibular mesoderm of the elasmobranchia includes the gastral mesoderm (homologous to III and some subsequent segments of Brachiostoma lanceolata) and peristomal mesoderm. The mandibular mesoderm in higher vertebrates has the same composition, but their anterior larval segments disappear and are substituted by gastral part of the mandibular mesoderm.

Amphibians↗
PubMed1978

[Recapitulatory significance of coeloblastulas].

The problem is discussed whether in Metasoa evolution there was a blastea stage, or else they were of parenchymal structure from the very beginning. The author favours the colonal theory in Metasoa origin and, as their progressive form, he considers spherical colonies where the cells are not united by intracellular substance but have immediate contact with each other. There are two ways of flagellar cells union: by their lateral surfaces or by basal ends. With the first way of union, a rather large colony acquires inevitably the form of blastea. With the second way of union, the number of cells increases, the colony becomes either a homogenous parenchimella or a blastea. The possibility of both ways of evolutionary development were studied experimentally. The results of artificial mutant selection of zootrophic colonial Euglena, Anthophysa vegetans are represented. The author comes to the following conclusions from the results obtained: 1. In Metosoa phylogenesis a blastea-like stage should be present. 2. Recapitulatory significance of the coeloblastulas is evident.

Animals↗
PubMed1978

[Specific secretory inclusions in the pyloric portion of the mouse stomach].

Aldehyde-fuchsin stainable secretory granules were found in the epithelium of the pyloric part of the mouse stomach. The granules are PAS-negative and nonstainable with lead hematoxylin. In intact mice only a small zone of the pylorus is engaged in production of such granules. Alpha-adrenergic stimulation causes expansion of the zone containing the granules. In mice exposed to general chilling after the propanolol injections there is a sharp extension of the zone in which the specific granules are distributed.

Animals↗
PubMedDate not supplied

[The tomitsid treatment of chronic cystitis in children].

The clinical efficiency of tomicid used in the treatment of childhood cystitis was examined by employing clinical, endoscopic, microbiological, and immunological findings. A total of 140 children were examined. These include 78 with chronic obstructive pyelonephritis without cystitis and 62 with chronic cystitis. The urinary bladder was instilled with reference tomicid solution in 18 children with chronic cystitis during 10-12 days. Tomicid was found to produce bactericidal and anti-inflammatory effects. The immunomodulating effect was shown mainly in young children (aged 1-6 years). The lack of toxic and adverse effects of the drug allows one to recommend for use in pediatric urologic practice.

Adjuvants, Immunologic↗