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Biomedical subjects

I N Karaban'

Publications and source records attributed to I N Karaban'.

At least 19 recordsLinked to original sources
PubMed2006

Two phases of the contingent negative variation in humans: association with motor and mental functions.

The question of the relationship between contingent negative variation and the mechanisms controlling motor and mental functions has received inadequate study. The aims of the present work were to investigate the relationship between the early and late phases of contingent negative variation and the state of motor and mental functions in patients with Parkinson's disease and to study the effects of levodopa on contingent negative variation. Patients with Parkinson's disease showed significant decreases in the amplitudes and areas of both phases of contingent negative variation as compared with subjects of similar age. Correlation analysis demonstrated a negative relationship between the extent of impairment of coordinatory muscle interactions and the amplitudes of both phases of this variation (p < 0.01). There was a positive relationship between the magnitudes of both phases and the state of mental functions, particularly memory (p < 0.05). Treatment of patients with Parkinson's disease with levodopa was followed by a significant increase in the late phase (p < 0.05). The results obtained here provide evidence for the important role of structures supporting both direct motor control and mental functions in forming both phases of contingent negative variation. The greater effect of levodopa on the late phase of contingent negative variation suggests that the efferent system of the basal ganglia has a greater role in generating the late phase than in organizing the early phase of the variation.

Acoustic Stimulation↗
PubMed2005

[Two phases of the contingent negative variation in humans: connection with motor and mental functions].

The question of dependence of the contingent negative variation (CNV) on the regulating mechanisms of motor and mental functions is not sufficiently studied. The tasks of the present work were: to investigate the dependence of the CNV early and late phases on the state of motor and mental functions in patients with Parkinson's disease (PD), and to elucidate the levodopa influence on the CNV parameters. 18 healthy subjects and 56 patients with PD were studied. In PD patients, significant reductions of amplitudes and squares of two CNV phases were observed. A negative correlation of the degree of coordinating muscle relationships disturbance with amplitudes of two CNV phases was found (p < 0.01). A positive interdependence between values of the both CNV phases and the state of mental functions was established, memory in particular (p < 0.05). After levodopa administration in PD patients, the early CNV phase did not significantly change, whereas the late CNV phase significantly increased (p < 0.05). Results of the investigation suggest an important role of the structures ensuring both direct motor control and mental functions in two CNV phases formation. A more obvious levodopa influence on the late CNV phase suggest participation of the basal ganglia efferent system in generation of the late CNV phase rather than in organization of the early CNV phase.

Aged↗
PubMed2004

[Effect of cerebrolysin on the electroencephalographic indices of brain activity in Parkinson's disease].

Cerebrolysin is a brain-derived peptide drug that increases the BBB-GLUT1 and MAP2 genes expression, thus exerting a neuroprotective effect. The present study aimed at investigating in patients with Parkinson's disease (PD) influence of Cerebrolysin infusions (intravenously, 10 ml during 10 days) combined with levodopa treatment on the electroencephalographic (EEG) indices of brain activity: P300 potential, contingent negative variation (CNV) and recovery functions of the cortical auditory evoked potentials, which reflect the postexcitatory inhibition at the paired stimulation. Nineteen PD patients, mean age 61.4 +/- 1.7 years; disease stage according to M.M. Hoehn and M.D. Yahr, 1967-2.2 +/- 0.1) and 18 age-matched healthy controls were studied. In the patients with essential differences of the EEG indices, comparing to the normal values, statistically significant changes were revealed: a decrease of P300 latency from 419.4 +/- 23.5 to 356.3 +/- 18.4 ms (8 patients, 42%); an increase of CNV duration from 423.1 +/- 93.3 to 600.6 +/- 38.5 ms; 2-fold increase of CNV mean amplitude and 3-fold increase of CNV square (8 patients, 42%) and strengthening of postexcitatory inhibition in auditory system at the paired stimulation (13 patients, 68%). In conclusion, Cerebrolysin may be recommended as an additional neuroprotective drug for brain functions improvement in the complex pathogenetic therapy of earlier PD stages.

Aged↗
PubMed2002

[The use of amantadine sulfate in combined therapy of Parkinson's disease].

The efficacy of PK-Merz medication has been studied in 17 patients with Parkinson's disease (PD), who have developed a resistance to levodopa as a result of a long-term treatment. The efficacy was evaluated according to clinical symptoms (UPDRS) and electromyography (EMG) indices. The summary motor score measured by UPDRS estimated as 49-79 (58.1 +/- 3.2) one hour after a single levodopa/carbidopa intake, decreased to 36-65 (45.2 +/- 2.9, p < 0.05) after levodopa/carbidopa combination with i.v. PK-Merz infusion. The biceps and triceps resting EMG amplitude and values of its variance also decreased significantly (p < 0.01). The percentage of the registered burst muscle discharges of 4-7 Hz frequency reduced from 32 to 13%. Under functional stress, the reflex antagonist muscle co-activation decreased in the majority of the patients. Selective correlations were found between the EMG indices and some UPDRS PD symptom scores. PK-Merz improves both motor functions and muscle coordination in PD.

Aged↗
PubMed1994

[Serotonin antibodies and their possible role in parkinsonism].

Serotonin antibodies (SAb) were found in the blood sera of middle-aged and elderly parkinsonian patients. The incidence of Sab in young and middle-aged healthy subjects was less, but increasing with age. Injected into the rabbit caudate nuclei, Sab suppressed the main pathogenetic mechanism of parkinsonian syndrome, the generator of pathologically enhanced excitation (GPEE) and parkinsonian symptoms induced by the MPP injection into substantia nigra. The intracaudate injection of serotonin enhanced GPEE activity and parkinsonian syndrome. The role of serotoninergic system and Sab in parkinsonism is discussed.

1-Methyl-4-phenylpyridinium↗
PubMed1993

[Dopamine antibodies in parkinsonism patients and their possible role in the pathogenesis of the parkinsonian syndrome].

Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more expressed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance formation is discussed.

Adult↗
PubMed1991

[Dopamine antibodies in the pathogenesis of parkinsonism].

L-DOPA and dopamine (DA) binding antibodies were found in the blood serum of Parkinsonian patients and middle-aged and elderly normal persons. DA-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (generator of pathologically enhanced excitation) in these brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity, tremor). The serum gamma-globulins of Parkinsonian patients without Da-antibodies caused less pronounced EEG disturbances. Parkinsonian symptoms developed rarely and were shorter and less pronounced compared with the DA-antibody effect. The DA binding antibodies role in Parkinson's syndrome pathogenesis and is L-DOPA therapeutic tolerance formation was discussed.

Adult↗
PubMed1990

[Catecholamines in the blood of parkinsonism patients].

Data are reported on age aspects of blood catecholamine metabolism in parkinsonism patients of middle and elderly age. The content of adrenalin, noradrenalin, dopamine was determined in the blood plasma of 95 patients with parkinsonism and in 75 practically healthy persons of similar age (control). Changes were shown of metabolism biogenic amines depending on the level of drug correction of parkinsonism and stage of the clinical course of the disease.

Adult↗
PubMed1990

[Age-related features of the functional state of the brain in patients with circulatory encephalopathy].

Complex clinico-physiological examinations was performed in 300 patients of middle and old ages with early and pronounced dyscirculatory encephalopathy of atherosclerotic and, in most cases, hypertensive etiologies. The cerebral hemodynamics was found to be relatively independent of the central one in patients with early atherosclerotic encephalopathy; the level of the systemic circulation and that of the median regional cerebral flow were found to correlate in early and advanced hypertensive encephalopathy cases. The cerebral function was shown to be more associated with the cerebral flow in the early encephalopathy in elderly patients than in middle-aged ones. The individual and personal traits of the patients were largely related to the disease stage rather than to the predominant etiological factor.

Adult↗
PubMed1989

[Initial dyscirculatory encephalopathy in middle-aged and elderly patients (problems of early diagnosis and therapy)].

Combined clinicophysiological investigation was performed in IDE (195 patients) in order to assess the degree of cerebral circulation disorders and their impact on the levels of brain functional activity. The informative values of several quantitative indices of brain hemodynamics and neurodynamics were assessed with respect to the patients' age. Single administration and full course of cavinton and sermion (nicergoline) were effective as judged by cerebral circulation studies (133Xe clearance), brain bioelectric activity (EEG frequency integration analysis, visual evoked potentials). In senile patients, the effect of i.v. sermion administration was dose-dependent.

Aged↗
PubMed1983

[Clinico-physiologic features of the initial manifestations of incomplete blood-filling of the cerebral circulation in young and middle-age cerebral atherosclerosis patients].

A combined study of the function of the central nervous system was carried out in 250 young and middle-aged patients (40-59 years) presenting initial clinical manifestations of cerebral vascular atherosclerosis. The age of the subjects allowed the authors to conditionally refer them to a group of patients with early cerebral atherosclerosis (ECA). The cerebral bloodflow was studied by examining such parameters as 133Xe clearance, functional REG, EEG, orientation reaction and visual evoked potentials: the findings obtained made it possible to specify the role of hemodynamic disorders in the formation of neurologic defect at this stage of the disease. The data presented point to a considerable acceleration of the aging process in patients with ECA, i.e., the so-called premature aging, manifested in the fact that such patients appear to be 10-15 years older than their age as judged by many age parameters. The authors recommend wider application of functional methods for the examination of the nervous system and hemodynamics aimed at determining the orientation and tactics of therapeutic and prophylactic measures with a view of preventing the progression and complications of the disease.

Adaptation, Physiological↗
PubMed1981

[Bioelectrical activity of the brain during long-term observation of patients with early cerebral atherosclerosis].

Results of the first four-year stage of long-time (planned for 15 years) examinations of the brain bioelectrical activity in 97 patients (aged 40 to 59 years) with initial signs of cerebral atherosclerosis are presented. A relative stability of the oscillatory process regularities was ascertained at annual examinations and courses of etiopathogenetic therapy. The frequency parameters of the alpha-activity were found to undergo certain age charges that took place in the presence of the relative increase of the share of low-frequency and dominantless curves.

Adult↗