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Biomedical subjects

I N Perminova

Publications and source records attributed to I N Perminova.

8 recordsLinked to original sources
PubMed2001

Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid.

Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.

Air Pollutants, Occupational↗
PubMed2001

[Differences in individual sensitivity to the antimutagenic effect of retinol in lymphocytes from workers in contact with nickel compounds].

Individual sensitivity to nickel compounds was studied in workers employed in nickel industry. The mutagen sensitivity was inferred from the number of sister chromatid exchanges (SCEs), which was used to characterize the structural alterations of the chromosomes in workers' lymphocytes before and after administration of retinol for a month. The SCE number decreased after retinol administration in nine out of eleven workers.

Antimutagenic Agents↗
PubMed1998

[Repair processes in human cultured cells upon exposure to nickel salts and their modification].

The genetic activity of nickel sulfate was estimated from the viability, decreased DNA replication, and increased DNA repair synthesis in cultured human fibroblasts and peripheral blood lymphocytes. All but the viability tests showed the mutagenic effect of nickel sulfate. Pretreatment with ascorbic acid modified DNA repair synthesis and increased the viability of lymphocytes treated with nickel sulfate.

Cell Survival↗
PubMed1997

[Formation of sister chromatid exchanges and reparative DNA synthesis in workers exposed to nickel compounds].

In workers from a nickel processing plant, residents of the surrounding industrial zone, and a control group, levels of sister chromatid exchanges (SCE, 33 individuals) and DNA repair synthesis (DRS, 79 individuals) were estimated. Individual variations in SCE level did not correlate to the duration of exposure to nickel compounds or the level of pollution. A statistically significant increase of SCE level among smokers compared to nonsmokers was revealed. Workers exposed to nickel compounds were demonstrated to have a statistically significant increase in the inhibition of DNA repair synthesis.

Adult↗
PubMedDate not supplied

[Comparative od adaptive response to gamma-radiation and nickel sulfate treatment in human cells].

Increased viability of human cells (line rhabdomyosarcoma) to challenge doses of NiSO4 (10(-5)-10(-3) M) was formed when cells were preirradiated with low doses of gamma-radiation (10-14 cGy). Observed adaptive response was similar to radioadaptive response in human fibroblasts, pretreated with low doses of gamma-radiation and challenge dose of the same mutagen. Pretreatment with low concentration of NiSO4 induced in human fibroblasts increased resistance of DNA to the treatment with challenge doses of gamma-radiation and stimulated DNA repair synthesis after treatment with NiSO4 and 4-nitroquinoline-1-oxide. These data confirm the existence of cross-adaptation in the experiments with NiSO4.

Adaptation, Physiological↗
PubMedDate not supplied

[Biomonitoring of lymphocytes of workers exposed to nickel compounds and an approach to reduction of genetic effects].

While examining the workers of the fire nickel production contacting preferably with insoluble and weakly soluble compounds of nickel, inhibition of DNA repair and increased level of chromosome changes (micronucleus test) were detected. Decreasing of micronucleus number, which was higher in smokers, and tendency to the stimulation of DNA repair synthesis were revealed after 1-month course of ascorbic acid (1 g/day). A level of changes in chromosome structure in the control group was estimated using the index of sister chromatid exchanges (SCE): variation of initial values was in normal bounds (6-8 SCE per cell), after vitamin course it even slightly decreased. High individual variability of chromosome changes and susceptibility to ascorbic acid was found.

Air Pollutants, Occupational↗
PubMedDate not supplied

[Role of superoxide dismutase in maintaining cellular homeostasis upon exposure to gamma-rays and nickel sulfate].

It was shown that the inhibition of one of the main enzymes of antioxidant system--superoxide dismutasw (SOD)--increased the level of damage in gamma-irradiated and NiSO4-treated human cells. The viability of cells pretreated with inhibitor of SOD (TRIEN) decreased in the experiments with gamma-radiation and with NiSO4. DNA repair and replication involved in cell homeostasis also were suppressed in the cells with inhibited SOD. These data are served as proof of participation of SOD in the defence of human cells against oxidative radicals.

Cells, Cultured↗