[Role of urodynamic disorders of the lower urinary tract in the pathogenesis of pyelonephritis in children].
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Biomedical subjects
I N Pidevich
Publications and source records attributed to I N Pidevich.
[Pharmacologic analysis of the mechanism of development of serotonin diarrhea in the mouse].
Diarrhea that arises in mice given serotonin intravenously is not suppressed by tipindolol, LSD-25, ciproheptadine in doses in which these drugs block the D and T serotonin-reactive structures, or is not reduced by hexonium, thereby providing no evidence in favour of the reflex nature of the effect. Diarrhea is suppressed by morphine and atropine, thus pointing to the responsibility for its origin of M-serotoninoreactive structures of intestinal parasympathetic ganglia with subsequent involvement of the postganglionic cholinergic link.
Animals↗
[Effect of serotonin and its antagonists on bladder detrusor function].
In anesthetized dogs, intravenous administration of serotonin causes biphasic contraction of the urinary bladder followed by relaxation. The m-antagonist of serotonin, morphine inhibits the first phase of contraction but does not affect the second phase and relaxation. The T-antagonist tipindole exerts no effect on the serotonin-induced contraction and relaxation of the detrusor. The D-antagonists, LSD-25, dihydroergotamine, droperidol and cyproheptadine produce no effect on the first phase of contraction but inhibit the second one and successive relaxation of the urinary bladder detrusor. In addition to D-antagonists of serotonin, the relaxation of the detrusor is also suppressed by inderal and guanethidine which indicates the participation of the sympathetic component in the effect realization. The serotonin-induced relaxation of the detrusor is not suppressed by benzohexonium.
Animals↗