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Biomedical subjects

I N Potapova

Publications and source records attributed to I N Potapova.

At least 19 recordsLinked to original sources
PubMed1989

[Collagen and fibronectin of the liver in children with congenital fibrosis, an extrahepatic portal circulation block and post-hepatitis cirrhosis (an immunohistochemical study)].

Immunofluorescence techniques were used to examine the distribution of Types I, III, IV and V collagen and fibronectin in the liver biopsy specimens from children with congenital liver fibrosis (CLF), extrahepatic portal blood circulation block, and cirrhosis developed following viral hepatitis. Both common patterns and characteristic features of the development of sclerotic processes were established. The common feature is the development of periportal connective tissue (CT) fibrosis mainly at the expense of Types I, III and V collagen and the accumulation of Types I, III, IV, V collagen and fibronectin in the walls of sinusoids during their "collagenization". The distinctive characteristic of posthepatic cirrhosis is the location of fibronectin and Type IV collagen in fibrous CT. Characteristic of CLF is high fibronectin concentrations in the areas of CT neoplasms along the periphery of portal tracts.

Adolescent↗
PubMed1988

[Pathomorphology of congenital liver fibrosis in children].

Pathomorphology of congenital liver fibrosis (CLF) was studied basing on histological evaluation of 42 primary and secondary liver biopsies obtained from 26 CLF children aged 1-13. CLF age-specific complications, their variants and incidence rate as well as morphogenesis are outlined, e. g. cholangiolitis and secondary cirrhosis which are not rare in 7-13-year-old children. Presented is CLF staging.

Adolescent↗
PubMed1986

[Intravital morphological research in pediatrics].

On the basis of own and literature data the author analyses the importance and potential of morphological intravital studies of organs and tissues for the diagnosis, investigation of patho- and morphogenesis, prognosis and estimation of the efficacy of treatment of different diseases in children. Difficulties of verification of pathologic processes associated with anatomo-physiological peculiarities of a growing organism are also mentioned. The author provides grounds for usage of intravital morphological studies to assess the informative value of functional methods in examination of sick children.

Biopsy↗
PubMed1986

[Liver biopsies in the diagnosis of congenital and acquired pathology of the hepatobiliary system in children].

Analysis was made of the biopsy material from children with hepatobiliary pathology and the results are presented. Structural basis of fibrocholangiocystosis and mucoviscidosis is described. Specific hepatic lesion in lymphogranulomatosis was found to be very rare. The authors provide as with new information concerning liver morphometry for chronic hepatitis and cirrhosis, i. e. estimation of portal tract area and the proportional content of collagenous tissue in them.

Adolescent↗
PubMed1981

[Brain lesions in children under 2-years-old with perinatal encephalopathy and severe cerebral palsy].

The authors carried out clinical observations of 103 children with grave damages of the central nervous system. Twenty-five children died of intercurrent diseases. The results of pathomorphological examinations of the dead children's brain were compared with the clinical picture of grave forms of perinatal encephalopathy and infantile cerebral paralysis. Taking into consideration the pathological course of the pregnancy and labour in the children's mothers, the presence of the neurological symptoms since the very first days of the children's life, as well as the results of the pathomorphological examinations of the brain, one can conclude that it is a lingering inflammatory process (started as an intrauterine one in most children) that is the morphological base of these diseases.

Brain↗